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    Human monoclonal antibodies derived from human B cells and having neutralizing activity against influenza A viruses
    2.
    发明授权
    Human monoclonal antibodies derived from human B cells and having neutralizing activity against influenza A viruses 有权
    来自人B细胞并具有针对甲型流感病毒的中和活性的人单克隆抗体

    公开(公告)号：US09573991B2

    公开(公告)日：2017-02-21

    申请号：US13583529

    申请日：2011-03-07

    申请人： Shin Jae Chang ,  Jong Mook Kim ,  Kye Sook Yi ,  Hyun Joo Lee

    发明人： Shin Jae Chang ,  Jong Mook Kim ,  Kye Sook Yi ,  Hyun Joo Lee

    IPC分类号： C07K16/10 ,  A61K39/42 ,  G01N33/569 ,  A61K39/00

    CPC分类号： C07K16/1018 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56983 ,  G01N2333/11

    摘要： The present invention relates to human monoclonal antibodies derived from human B cells present in the blood of patients who had recovered from infection with influenza A viruses, wherein the monoclonal antibodies have neutralizing activity against influenza A viruses. The anti-influenza A virus monoclonal antibody of the present invention has binding and neutralizing activities against at least one influenza A virus selected from the group consisting of influenza A virus H1, H2 and H5 subtypes, and thus it is useful for the prevention and treatment of a disease caused by the influenza A virus and is also useful for diagnosis of influenza A virus infection.

    摘要翻译： 本发明涉及从甲型流感病毒感染中恢复的患者血液中存在的人B细胞的人单克隆抗体，其中所述单克隆抗体具有针对甲型流感病毒的中和活性。 本发明的抗A型流感病毒单克隆抗体对选自甲型流感病毒H1，H2和H5亚型的至少一种甲型流感病毒具有结合和中和活性，因此可用于预防和治疗 由甲型流感病毒引起的疾病，也可用于甲型流感病毒感染的诊断。