发明授权
- 专利标题： Auto-indicible expression system, and the use thereof for producing useful metabolites using a bacterium of the family enterobacteriaceae
- 专利标题（中）： 自动表达系统及其用于使用肠杆菌科的细菌产生有用的代谢物的用途
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申请号： US14499655申请日： 2014-09-29
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公开(公告)号： US09574216B2公开(公告)日： 2017-02-21
- 发明人: Elena Viktorovna Sycheva , Valery Vasilievich Samsonov , Ekaterina Alekseevna Savrasova , Natalia Sergeevna Eremina , Natalia Vladimirovna Geraskina , Natalia Viktorovna Stoynova
- 申请人： AJINOMOTO CO., INC.
- 申请人地址： JP Tokyo
- 专利权人： AJINOMOTO CO., INC.
- 当前专利权人： AJINOMOTO CO., INC.
- 当前专利权人地址： JP Tokyo
- 代理机构： Cermak Nakajima & McGowan LLP
- 代理商 Shelly Guest Cermak
- 优先权： RU2012112651 20120402
- 主分类号： C12P13/08
- IPC分类号： C12P13/08 ; C12N15/63 ; C12N15/70 ; C12P13/06
摘要：
The present invention describes a method for producing a useful metabolite using a bacterium of the family Enterobacteriaceae, particularly a bacterium belonging to the genus Escherichia, which has been modified to contain a gene(s) expression system including elements of the LysR-type protein-regulated transcriptional machinery modified in such a way that auto-inducible positive feedback regulation of the system is mediated by a coinducer. The method is suitable for producing branched-chain L-amino acids, particularly L-valine, L-isoleucine and L-leucine; and D-pantothenic acid.
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