Apparatus and associated methods relate to method of determining a treatment plan with Botulinum Toxin (BT) and other procedures able to modify facial expressions, the method includes using a series of facial images of a patient eliciting various expressions to select individual expressive features as candidates for modification, the selected expressive features mapping to muscles that are used to create such expressive features, the muscles mapping into related expressive features of facial images of the patient eliciting different expressions, the related expressive features being weighted so as to provide further information used in determining an optimum treatment dosing for each treatment location. In an illustrative example, the method may include mapping the facial image of the patient to a model image using facial markers. In an exemplary embodiment, the method may advantageously provide a treatment that results in optimum expressive features as revealed in many different expressions.