公开(公告)号：US20160007785A1

公开(公告)日：2016-01-14

申请号：US14326426

申请日：2014-07-08

申请人： Stefan Bradu ,  Ionel Teodorescu

发明人： Stefan Bradu ,  Ionel Teodorescu

IPC分类号： A47G23/02 ,  B65D1/26 ,  B65D81/32

CPC分类号： A47G23/0208 ,  A47G19/2205 ,  B65D81/3283

摘要： A drinking device comprising a first compartment to hold a first fluid, a second compartment to hold a second fluid independent of the first fluid, a vertical separation between the first and second compartments, a horizontal separation closing a part of the first compartment, an opening in the horizontal separation to allow flow of the first fluid, and a lip on an upper rim of the device and opposite to the horizontal separation and adjacent to the opening to allow ingestion of the first and second fluids. A method of oral delivery of a first fluid and a second fluid, said fluids having different taste flavors, comprising delivering the first fluid in a bolus head followed by delivering the second fluid in the bolus center, and then delivering the first fluid again in the bolus tail to mask the more unpleasant flavor.

摘要翻译： 一种饮用装置，包括用于保持第一流体的第一隔室，用于保持独立于第一流体的第二流体的第二隔室，第一和第二隔室之间的垂直间隔;封闭第一隔室的一部分的水平分隔件， 在水平分离中以允许第一流体流动，并且唇缘在装置的上边缘上并且与水平分离相反并且与开口相邻，以允许摄取第一和第二流体。 口腔递送第一流体和第二流体的方法，所述流体具有不同的味道味道，包括将第一流体输送到推注头中，然后将第二流体递送到推注中心，然后再次将第一流体递送至 弹丸尾巴掩盖更令人不快的味道。

公开(公告)号：US20150157259A1

公开(公告)日：2015-06-11

申请号：US14100885

申请日：2013-12-09

申请人： Stefan Bradu

发明人： Stefan Bradu

IPC分类号： A61B5/00 ,  A61B5/16

CPC分类号： A61B5/4839 ,  A61B5/0077 ,  A61B5/165 ,  A61B5/4519 ,  A61B5/743 ,  A61B2576/02

摘要： Apparatus and associated methods relate to method of determining a treatment plan with Botulinum Toxin (BT) and other procedures able to modify facial expressions, the method includes using a series of facial images of a patient eliciting various expressions to select individual expressive features as candidates for modification, the selected expressive features mapping to muscles that are used to create such expressive features, the muscles mapping into related expressive features of facial images of the patient eliciting different expressions, the related expressive features being weighted so as to provide further information used in determining an optimum treatment dosing for each treatment location. In an illustrative example, the method may include mapping the facial image of the patient to a model image using facial markers. In an exemplary embodiment, the method may advantageously provide a treatment that results in optimum expressive features as revealed in many different expressions.

摘要翻译： 装置和相关方法涉及用肉毒杆菌毒素（BT）和其他能够修饰面部表情的方法确定治疗计划的方法，所述方法包括使用引导各种表达的患者的一系列面部图像来选择个体表达特征作为 修改，所选择的表现特征映射到用于创建这样的表现特征的肌肉，将肌肉映射到引起不同表达的患者的面部图像的相关表现特征中，相关表现特征被加权，以便提供用于确定的进一步信息 每个治疗位置的最佳治疗剂量。 在说明性示例中，该方法可以包括使用面部标记将患者的面部图像映射到模型图像。 在一个示例性实施例中，该方法可以有利地提供一种治疗，其导致在许多不同表达中所揭示的最佳表现特征。

公开(公告)号：US20060258841A1

公开(公告)日：2006-11-16

申请号：US10542239

申请日：2004-01-16

申请人： Josef Michl ,  Stefan Bradu ,  Raquib Hannan ,  Matthew Pincus

发明人： Josef Michl ,  Stefan Bradu ,  Raquib Hannan ,  Matthew Pincus

IPC分类号： C07K14/82 ,  C07K16/30

CPC分类号： C07K16/303 ,  A61K47/6817 ,  A61K47/6859 ,  A61K51/1057 ,  A61K2039/505 ,  C07K14/47 ,  C07K2317/24 ,  C07K2317/734 ,  G01N33/57438 ,  G01N2333/705

摘要： The present invention is directed to an antigen found on the surface of rat and human pancreatic cancer cells and provides antibodies of high specificity and selectivity to this antigen as well as hybridomas secreting the subject antibodies. Methods for both the diagnosis and treatment of pancreatic cancer are also provided. This tissue marker of pancreatic adenocarcinoma, an approximately 43.5 kD surface membrane protein designated PaCa-Ag1, is completely unexpressed in normal pancreas but abundantly expressed in pancreatic carcinoma cells. Moreover, a soluble form of PaCa-Ag1 exists, having a molecular weight about 36 to about 38 kD, that is readily identified in sera and other body fluids of pancreatic cancer patients, using a subject antibody.

摘要翻译： 本发明涉及在大鼠和人胰腺癌细胞表面上发现的抗原，并且提供对该抗原以及分泌本发明抗体的杂交瘤具有高特异性和选择性的抗体。 还提供了胰腺癌诊断和治疗方法。 胰腺腺癌组织标志物，一种约43.5 kD的表皮膜蛋白，称为PaCa-Ag1，在正常胰腺中完全未表达，但在胰腺癌细胞中大量表达。 此外，使用受试抗体，存在可溶形式的PaCa-Ag1，其分子量约36至约38kD，其易于在胰腺癌患者的血清和其它体液中鉴定。

公开(公告)号：US09579057B2

公开(公告)日：2017-02-28

申请号：US14100885

申请日：2013-12-09

申请人： Stefan Bradu

发明人： Stefan Bradu

IPC分类号： A01B5/00 ,  A01B5/16 ,  A61B5/00 ,  A61B5/16

CPC分类号： A61B5/4839 ,  A61B5/0077 ,  A61B5/165 ,  A61B5/4519 ,  A61B5/743 ,  A61B2576/02

摘要： Apparatus and associated methods relate to method of determining a treatment plan with Botulinum Toxin (BT) and other procedures able to modify facial expressions, the method includes using a series of facial images of a patient eliciting various expressions to select individual expressive features as candidates for modification, the selected expressive features mapping to muscles that are used to create such expressive features, the muscles mapping into related expressive features of facial images of the patient eliciting different expressions, the related expressive features being weighted so as to provide further information used in determining an optimum treatment dosing for each treatment location. In an illustrative example, the method may include mapping the facial image of the patient to a model image using facial markers. In an exemplary embodiment, the method may advantageously provide a treatment that results in optimum expressive features as revealed in many different expressions.

摘要翻译： 装置和相关方法涉及用肉毒杆菌毒素（BT）和其他能够修饰面部表情的方法确定治疗计划的方法，所述方法包括使用引导各种表达的患者的一系列面部图像来选择个体表达特征作为 修改，所选择的表现特征映射到用于创建这样的表现特征的肌肉，将肌肉映射到引起不同表达的患者的面部图像的相关表现特征中，相关表现特征被加权，以便提供用于确定的进一步信息 每个治疗位置的最佳治疗剂量。 在说明性示例中，该方法可以包括使用面部标记将患者的面部图像映射到模型图像。 在一个示例性实施例中，该方法可以有利地提供一种治疗，其导致在许多不同表达中所揭示的最佳表现特征。

公开(公告)号：US20070036809A1

公开(公告)日：2007-02-15

申请号：US10542586

申请日：2004-01-29

申请人： Josef Michl ,  Stefan Bradu

发明人： Josef Michl ,  Stefan Bradu

IPC分类号： A61K39/00 ,  C12P21/04

CPC分类号： A61K31/675 ,  A61K39/00 ,  A61K2039/545 ,  C07K16/303

摘要： The present invention provides methods for directing the immune response of an animal towards immunologically weak or rare antigens such as tumor antigens. The methods combine subtractive immunization with hyperimmunization and result in the controlled or directed production of target-specific antibodies, helper T cells (CD4+-T lymphocytes) and cytotoxic T cells (CD8+-T lymphocytes). Also provided by the present invention are untransformed and transformed cell lines, and growth media necessary to grow the untransformed cell line in a differentiated state. Monoclonal antibodies which react with different neoplastic cell lines and hybridomas producing such antibodies are also provided.

摘要翻译： 本发明提供了将动物的免疫应答引导到免疫弱或罕见抗原如肿瘤抗原的方法。 所述方法将减免免疫与超免疫结合相结合，并导致靶特异性抗体，辅助性T细胞（CD4 + T淋巴细胞）和细胞毒性T细胞（CD8 + SUP + -T淋巴细胞）。 本发明还提供未转化和转化的细胞系，以及生长未分化状态的未转化细胞系所需的生长培养基。 还提供了与不同的肿瘤细胞系反应的单克隆抗体和产生这种抗体的杂交瘤。