Invention Grant
- Patent Title: SERS, fluorescence, absorption, and luminescence detection with flow-through multi-hole capillaries
- Patent Title (中): SERS，荧光，吸收和发光检测与流通多孔毛细管
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Application No.: US14357151Application Date: 2012-11-08
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Publication No.: US09581592B2Publication Date: 2017-02-28
- Inventor: Xudong Fan , Yunbo Guo , Maung Kyaw Khaing Oo
- Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Applicant Address: US MI Ann Arbor
- Assignee: The Regents Of The University Of Michigan
- Current Assignee: The Regents Of The University Of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agency: Harness, Dickey & Pierce, PLC
- International Application: PCT/US2012/064200 WO 20121108
- International Announcement: WO2013/070948 WO 20130516
- Main IPC: G01N33/543
- IPC: G01N33/543 ; G01N21/31 ; G01N21/64 ; G01N21/65 ; G01N21/03
Abstract:
3-dimensional surface-enhanced Raman scattering (SERS), as well as absorption/fluorescence/luminescence detection is carried out using a platform based on nanoparticle-functionalized flow-through multi-hole capillaries for rapid analyte detection. The configuration provides an increased active area and fluidic channels for efficient sample delivery, and also confines and transmits light for a large signal accumulation. Using a capillary consisting of thousands of micron-sized holes adsorbed with gold nanoparticles, a detection limit better than 100 fM is achieved.
Public/Granted literature
- US20140322729A1 SERS, FLUORESCENCE, ABSORPTION, AND LUMINESCENCE DETECTION WITH FLOW-THROUGH MULTI-HOLE CAPILLARIES Public/Granted day:2014-10-30
Information query
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