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    SERS, fluorescence, absorption, and luminescence detection with flow-through multi-hole capillaries
    3.
    发明授权
    SERS, fluorescence, absorption, and luminescence detection with flow-through multi-hole capillaries 有权
    SERS，荧光，吸收和发光检测与流通多孔毛细管

    公开(公告)号：US09581592B2

    公开(公告)日：2017-02-28

    申请号：US14357151

    申请日：2012-11-08

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： Xudong Fan ,  Yunbo Guo ,  Maung Kyaw Khaing Oo

    IPC: G01N33/543 ,  G01N21/31 ,  G01N21/64 ,  G01N21/65 ,  G01N21/03

    CPC classification number: G01N33/54373 ,  G01N21/31 ,  G01N21/64 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/0346

    Abstract: 3-dimensional surface-enhanced Raman scattering (SERS), as well as absorption/fluorescence/luminescence detection is carried out using a platform based on nanoparticle-functionalized flow-through multi-hole capillaries for rapid analyte detection. The configuration provides an increased active area and fluidic channels for efficient sample delivery, and also confines and transmits light for a large signal accumulation. Using a capillary consisting of thousands of micron-sized holes adsorbed with gold nanoparticles, a detection limit better than 100 fM is achieved.

    Abstract translation: 使用基于纳米颗粒功能化的流通多孔毛细管的平台进行三维表面增强拉曼散射（SERS）以及吸收/荧光/发光检测，用于快速分析物检测。 该配置提供增加的有效面积和流体通道用于有效的样品输送，并且还限制和透射用于大信号积聚的光。 使用吸附有金纳米颗粒的数千微米尺寸的孔组成的毛细管，达到优于100fM的检测限。

    Devices and methods for adaptive micro-gas chromatography
    4.
    发明授权
    Devices and methods for adaptive micro-gas chromatography 有权
    适应性微气相色谱的装置和方法

    公开(公告)号：US09341604B2

    公开(公告)日：2016-05-17

    申请号：US14357157

    申请日：2012-11-08

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： Xudong Fan ,  Yogesh B. Gianchandani ,  Jing Liu

    IPC: G01N30/46 ,  G01N30/60 ,  G01N30/72

    CPC classification number: G01N30/461 ,  G01N30/46 ,  G01N30/463 ,  G01N30/465 ,  G01N30/466 ,  G01N30/468 ,  G01N30/6095 ,  G01N30/72

    Abstract: The present disclosure provides adaptive methods for gas chromatography analysis of a gas sample comprising one or more target analytes (such as a micro-gas chromatography) and adaptive gas chromatography devices for carrying out such analytical methods. Broadly, the system can regulate flow into a downstream chromatographic column by detecting one or more upstream conditions. For example, one adaptive chromatography device comprises a first column, a modulator component, and a second column. A first detector or sensor detects the presence of target analytes upstream from the second column, while a second detector detects the presence of target analytes eluted from the second column. The modulator component assembly is responsive to an output generated by the first detector and adaptively regulates fluid flow into the second column. Such adaptive chromatography (micro-GC) systems have higher separation speed, better analyte identification capability, and far greater energy savings.

    Abstract translation: 本公开提供了用于气体样品的气相色谱分析的自适应方法，所述气体样品包含一种或多种靶分析物（例如微气相色谱）和用于进行这种分析方法的适应性气相色谱装置。 通常，系统可以通过检测一个或多个上游条件来调节流入下游色谱柱的流量。 例如，一个自适应色谱装置包括第一列，调制器组件和第二列。 第一检测器或传感器检测来自第二列上游的目标分析物的存在，而第二检测器检测从第二列洗脱的目标分析物的存在。 调制器部件组件响应于由第一检测器产生的输出并且自适应地调节流入第二列的流体流。 这种自适应色谱（micro-GC）系统具有更高的分离速度，更好的分析物识别能力和更大的能量节省。

    Laser emission based microscope
    5.
    发明授权
    Laser emission based microscope 有权

    公开(公告)号：US11536659B2

    公开(公告)日：2022-12-27

    申请号：US16473584

    申请日：2017-12-27

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： Xudong Fan ,  Yu-Cheng Chen ,  Qiushu Chen

    IPC: G01N21/64 ,  G02B21/00 ,  G02B21/34

    Abstract: Laser emission based microscope devices and methods of using such devices for detecting laser emissions from a tissue sample are provided. The scanning microscope has first and second reflection surfaces and a scanning cavity holding a stationary tissue sample with at least one fluorophore/lasing energy responsive species. At least a portion of the scanning cavity corresponds to a high quality factor (Q) Fabry-Pérot resonator cavity. A lasing pump source directs energy at the scanning cavity while a detector receives and detects emissions generated by the fluorophore(s) or lasing energy responsive species. The second reflection surface and/or the lasing pump source are translatable with respect to the stationary tissue sample for generating a two-dimensional scan of the tissue sample. Methods for detecting multiplexed emissions or quantifying one or more biomarkers in a histological tissue sample, for example for detection and diagnosis of cancer, or other disorders/diseases are provided.

    Assay plate and uses thereof
    7.
    发明授权
    Assay plate and uses thereof 有权

    公开(公告)号：US10730044B2

    公开(公告)日：2020-08-04

    申请号：US15944962

    申请日：2018-04-04

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： Maung Kyaw Khaing Oo ,  Xudong Fan

    IPC: B01L3/00

    Abstract: An assay plate assembly comprising a plurality of microfluidic modules arranged in a rectilinear matrix of rows and columns microfluidic channels. Each microfluidic module has an inlet well leading to a serpentine microfluidic channel that is set at a cant angle. The well is laterally offset from the detection area to avoid optical interference. The geometric center of each detection area is positioned according to ANSI/SLAS standards for well-centers. A drain from each microfluidic channel is located so that it does not interfere with any detection areas. An array of optically-transmissive micro-posts are disposed within each microfluidic channel. The micro-posts extend perpendicularly from the top surface of the top plate toward the underside and are equally distributed throughout the entire detection area. The plate assembly provides reduced assay time and sample volume, and increased sensitivity and specificity in biological and chemical assays.

    Miniaturized discharge photo-ionization detector
    8.
    发明授权
    Miniaturized discharge photo-ionization detector 有权

    公开(公告)号：US10718738B2

    公开(公告)日：2020-07-21

    申请号：US15685139

    申请日：2017-08-24

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： Xudong Fan ,  Hongbo Zhu ,  Katsuo Kurabayashi

    IPC: G01N27/64 ,  G01N27/66

    Abstract: A discharge ionization current detector for ionizing and detecting a sample component where the sample component is ionized by UV light is provided. The detector includes a UV light source, and a microfluidic channel having a first surface including a conducting or semiconducting material and an opposing second surface including a conducting or semiconducting material, one of the first surface and the second surface being a collection electrode and the other of the first surface and the second surface being a bias electrode, the microfluidic channel being configured to receive a sample component. The microfluidic channel is in fluid communication with the UV light source such that, when activated, UV light from the UV light source can enter the microfluidic channel and ionize the sample component, which releases an electron, and the ionized sample component and electron are detected by the collection and bias electrodes.

    Microfluidic photoionization detector
    9.
    发明授权
    Microfluidic photoionization detector 有权

    公开(公告)号：US10705061B2

    公开(公告)日：2020-07-07

    申请号：US15571792

    申请日：2016-05-04

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： Xudong Fan ,  Hongbo Zhu ,  Robert Nidetz ,  Katsuo Kurabayashi ,  Menglian Zhou ,  Jiwon Lee

    IPC: G01N30/64 ,  G01N30/74 ,  G01N27/66 ,  G01N27/68 ,  G01N30/60

    Abstract: A rapid flow-through, highly sensitive microfluidic photoionization detector (PID) which is micro-fabricated directly onto a substrate, such as a conductive silicon wafer, is provided. The microfluidic PID has an ionization chamber volume of less than 9 μL. The microfluidic PID may have a flow through design with a microfluidic channel defines a serpentine pattern on the substrate. The flow through design of the microfluidic PID results in negligible dead volume, thus allowing a shortened response time over existing commercially available designs. Such microfluidic PIDs are particularly useful with gas chromatography (GC), including microGC and multi-dimensional microGC systems. Methods for calibrating PIDs are also provided.

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