Disclosed is a main synchronization sequence design method for global covering multi-beam satellite LTE, comprising the follow steps: extending a standard Zadoff-Chu sequence to a generalized Zadoff-Chu sequence so as to obtain an initial candidate main synchronization sequence set of more candidate sequences; gradually narrowing down the candidate main synchronization sequence set according to a selection standard of a main synchronization sequence to obtain a final candidate main synchronization sequence set; and obtaining a main synchronization sequence set with optimal eclectic performance and complexity from the final candidate main synchronization sequence set. According to the present invention, a main synchronization sequence with optimal eclectic performance and calculation complexity can be designed for a global covering same-frequency networking multi-beam satellite LTE system.