A method and system for tailoring an injection protocol to an individual patient, wherein the injection protocol is administered in connection with a diagnostic imaging procedure. The method includes: administering a test injection of a fluid including a contrast enhancing fluid into the patient at an administration site; performing a test scan of one or more regions of interest of the patient as the fluid propagates through the patient to obtain scan data; determining from the scan data an enhancement output from each of the one or more regions of interest at a plurality of points in time as a result of the propagation of the fluid through the patient; and determining the injection protocol for the patient based at least in part upon the enhancement output from each of the one or more regions of interest at each of the plurality of points in time.