- 专利标题: Pyrrole derivatives as alpha 7 nAChR modulators
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申请号: US14655878申请日: 2014-01-13
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公开(公告)号: US09617211B2公开(公告)日: 2017-04-11
- 发明人: Neelima Sinha , Navnath Popat Karche , Anil Kashiram Hajare , Baban Rupaji Thube , Dnyaneshwar Changdeo Bhanage , Venkata P. Palle , Rajender Kumar Kamboj
- 申请人: Lupin Limited
- 申请人地址: IN Mumbai
- 专利权人: Lupin Limited
- 当前专利权人: Lupin Limited
- 当前专利权人地址: IN Mumbai
- 代理机构: Leydig, Voit & Mayer, Ltd.
- 优先权: IN52/KOL/2013 20130116
- 国际申请: PCT/IB2014/058230 WO 20140113
- 国际公布: WO2014/111839 WO 20140724
- 主分类号: C07D207/333
- IPC分类号: C07D207/333 ; A61K45/06 ; A61K31/403 ; A61K31/40 ; C07D403/06 ; C07D207/33 ; C07D207/416
摘要:
Disclosed is a compound of formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and m are as described herein, as a modulator of nicotinic acetylcholine receptors particularly α7 subtype, its tautomeric forms, its stereoisomers, its pharmaceutically acceptable salts, its pharmaceutical composition, and its combinations with suitable medicaments. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like.
公开/授权文献
- US20150361041A1 Pyrrole Derivatives as Alpha 7 NACHR Modulators 公开/授权日:2015-12-17
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