-
公开(公告)号:US20230088365A1
公开(公告)日:2023-03-23
申请号:US17961978
申请日:2022-10-07
发明人: Tomomi Ikemoto , Misayo Sera , Naohiro Fukuda , Hideya Mizufune , Toshiaki Nagata , Takeshi Yamasaki
IPC分类号: C07D207/337 , C07D207/333 , C07D207/34 , C07D207/36 , C07D401/12 , C07D207/30 , C07D207/48
摘要: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.
-
公开(公告)号:US11524938B2
公开(公告)日:2022-12-13
申请号:US17067434
申请日:2020-10-09
发明人: Stefan Werner , Stefanie Mesch , Arwed Cleve , Nico Bräuer , Simon Anthony Herbert , Markus Koch , Henrik Dahllöf , Maren Osmers , Elizabeth Hardaker , Anton Lishchynskyi
IPC分类号: C07D213/64 , C07D403/06 , C07D231/14 , C07D231/16 , C07D231/18 , C07D233/61 , C07D233/64 , C07D233/68 , C07D401/04 , C07D403/04 , C07D405/06 , C07D239/34 , C07D249/06 , C07D249/08 , C07D249/14 , C07D471/04 , C07D261/08 , C07D271/06 , C07C311/46 , C07F5/02 , C07D207/416 , C07D231/56 , C07D213/85 , C07D277/56 , C07D249/20 , C07D213/60 , C07C311/17 , C07D213/61 , C07D239/30 , C07D239/42 , C07D249/10 , C07D213/65 , C07D249/12 , C07D233/16 , C07C323/62 , C07D237/08 , C07D213/40 , C07D239/26 , C07D235/06 , C07C311/40 , C07D213/74 , C07D405/04 , C07D271/04 , C07D277/26 , C07D249/18 , C07D277/34 , C07D275/02 , C07D263/32 , C07D231/38 , C07D207/333 , A61P29/00 , C07D235/08 , C07D401/12 , C07D231/12
摘要: Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.
-
公开(公告)号:US20220324806A1
公开(公告)日:2022-10-13
申请号:US17626516
申请日:2020-07-10
IPC分类号: C07D213/30 , C07D307/42 , C07C39/24 , C07D239/26 , C07D333/16 , C07D231/12 , C07D333/56 , C07D261/08 , C07C255/53 , C07D257/04 , C07C43/225 , C07D295/033 , C07C43/205 , C07D271/06 , C07D271/113 , C07D249/08 , C07D207/333 , C07D277/26 , C07D209/12 , C07D235/18 , C07D473/00 , C07D305/06 , C07D303/14 , C07D203/10 , C07D263/14 , C07D309/32 , C07D241/12
摘要: The current application relates to cannabinoid derivatives of formula (I) and pharmaceutical compositions comprising the same. The cannabinoid derivative can be used for the treatment of diseases associated with cannabinoid receptor such as pain, ADHD/ADD, alcohol use disorder, anxiety disorder, and dementias.
-
公开(公告)号:US20210188763A1
公开(公告)日:2021-06-24
申请号:US16767919
申请日:2018-11-29
发明人: John P. Chute , Michael E. Jung , Emelyne Diers , Hyo Jin Gim , Martina Roos
IPC分类号: C07C225/20 , C07F7/12 , C07C311/39 , C07D307/52 , C07D317/66 , C07D231/12 , C07C205/43 , C07D207/333 , C07D333/22 , C07D249/06 , C07C233/88 , C07C233/15 , C07C225/22 , C07D211/58 , C07C233/66 , C07C255/58 , C07D231/56 , C07D213/74 , C07D401/06 , C07D333/36 , C07D213/50 , A61P7/06
摘要: The invention relates to compounds that promote hematopoietic regeneration. The invention further relates to methods of promoting hematopoietic regeneration using the novel compounds of the invention.
-
5.
公开(公告)号:US20200223797A1
公开(公告)日:2020-07-16
申请号:US16347117
申请日:2017-11-09
IPC分类号: C07D207/323 , C07D207/333
摘要: Adducts are described, obtainable from the reaction product of a secondary amine and a diketone, with carbon allotropes in which the carbon is sp2 hybridized, such as graphene, graphite, fullerene, carbon nanotubes and the like, and an inorganic oxide-hy-droxide. A process for preparing said adducts is also described.
-
公开(公告)号:US10532996B2
公开(公告)日:2020-01-14
申请号:US15402628
申请日:2017-01-10
发明人: Megan Foley , Bradley Tait , Matthew Cullen
IPC分类号: C07D403/06 , C07D405/06 , C07D401/06 , C07D249/06 , C07D207/333 , C07D207/337 , C07D231/12 , C07D263/32 , C07D275/02 , C07D295/185 , C07D333/20 , C07D471/04 , C07D333/22
摘要: The present invention is directed to compounds having the Formulae (Ia-Ie), (II), (IIIa-IIId), (IVa-IVc), (Va-Vb), (VIa-VIe), (VII), (VIIIa-VIIIc), and (IX), pharmaceutically acceptable salts, prodrugs and solvates thereof, compositions of any of thereof and methods for the treatment of a condition associated with a dysfunction in proteostasis comprising an effective amount of these compounds.
-
公开(公告)号:US20190389797A1
公开(公告)日:2019-12-26
申请号:US16553718
申请日:2019-08-28
发明人: Shriprakash Dhar Dwivedi , Ramesh Chandra Singh , Rajendra Gokalbhai Chavda , Jagdish Maganlal Patel , Daya Ram Pal , Pranav Jitendra Gangwar , Vikas Patel , Vishwadeepak Rama Pati Tripathi
IPC分类号: C07D207/333 , C07D207/32
摘要: The present invention provides pyrroles having hypolipidemic hypocholesteremic activities. The invention provides saroglitazar and its pharmaceutically acceptable salts, hydrates, solvates, polymorphs or intermediates thereof. The invention also provides a process for the preparation of saroglitazar. The invention further provides intermediates as well process for preparation thereof.
-
公开(公告)号:US20190300479A1
公开(公告)日:2019-10-03
申请号:US16317269
申请日:2017-07-13
发明人: Neil James Parry , Paolo Pantalone , Paul Williams
IPC分类号: C07D207/44 , C07D207/333 , A61K9/00 , A61K31/402 , A61K31/4015 , A61P31/04 , A61P11/00
摘要: Lactams for use in the treatment of respiratory tract infections, including chronic lung infections in patients having cystic fibrosis.
-
公开(公告)号:US10351568B2
公开(公告)日:2019-07-16
申请号:US14933671
申请日:2015-11-05
IPC分类号: C07D487/04 , C07D207/333 , C07D207/335 , C07D209/44 , C07D233/64 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D471/04 , C07D209/08 , C07D401/04 , G01N33/573
摘要: Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies.
-
公开(公告)号:US20190194386A1
公开(公告)日:2019-06-27
申请号:US16330833
申请日:2017-09-08
发明人: Jadranka Travas-Sejdic , David Edward Williams , Nihan Aydemir , David Barker , Wai Chi Eddie Chan , Clive William Evans
IPC分类号: C08G61/12 , C07D207/323 , C07D333/08 , C12Q1/6844 , B01L7/00 , C12Q1/6862 , C07D333/16 , C07D207/333 , G01N27/327
CPC分类号: C08G61/126 , B01L7/52 , B01L2300/0645 , B01L2300/0663 , C07D207/323 , C07D207/333 , C07D333/08 , C07D333/16 , C08G61/124 , C08G2261/12 , C08G2261/1424 , C08G2261/1426 , C08G2261/1432 , C08G2261/1452 , C08G2261/312 , C08G2261/3221 , C08G2261/3223 , C08G2261/44 , C08G2261/94 , C12Q1/6844 , C12Q1/6862 , C25D9/02 , G01N27/3277
摘要: The present invention generally relates to the field of conducting polymers. More specifically, the present invention relates to polymerisable monomers comprising a probe capable of binding one or more nucleic acids or comprising a nucleic acid or an analogue thereof, conducting polymers comprising monomer units of such monomers, and methods of making such polymers. The present invention also relates to sensors comprising the polymers, sensor systems comprising the sensors, methods of making the sensors, and methods for determining the presence or absence or amount of targets employing the sensors. The present invention also relates to methods, systems and apparatuses for amplifying nucleic acids employing the conducting polymers.
-
-
-
-
-
-
-
-
-