The present disclosure includes systems and techniques relating to calibrating I/Q mismatches in communication systems. In some implementations, a reference signal to be transmitted by a transmitter (Tx) is identified. A loopback signal corresponding to the reference signal is generated by passing the reference signal through the TX and a receiver (Rx). The loopback signal includes an additional signal that distinguishes an in-phase/quadrature (I/Q) mismatch caused by the Tx (Tx I/Q mismatch) from an I/Q mismatch caused by the Rx (RX I/Q mismatch). A set of Tx I/Q mismatch parameters and a set of Rx I/Q mismatch parameters are determined based on the reference signal and the loopback signal, using the additional signal. A Tx signal is calibrated based on the set of Tx I/Q mismatch parameters, while a Rx signal is calibrated based on the set of Rx I/Q mismatch parameters, independently from the calibrating the Tx signal.