The present invention discloses a method and a device for handover of a mobile terminal between base stations, which relates to the field of communications technologies and can realize handover of user equipment between base stations in a condition of ensuring that business services of a neighboring base station and a target base station are not interrupted. An embodiment of the present invention includes: a source base station obtains a designated channel resource, and, by negotiating with a target base station and a neighboring base station, determines to send a handover command to user equipment. Embodiments of the present invention are mainly applied to a handover process of a base station.