- 专利标题: Process for the stereoselective preparation of a pyrazole-carboxamide
-
申请号: US14892386申请日: 2014-06-19
-
公开(公告)号: US09637457B2公开(公告)日: 2017-05-02
- 发明人: Raphael Dumeunier , Jilali Kessabi , Sebastian Volker Wendeborn , Hannes Nussbaumer
- 申请人: Syngenta Participations AG
- 申请人地址: CH Basel
- 专利权人: Syngenta Participations AG
- 当前专利权人: Syngenta Participations AG
- 当前专利权人地址: CH Basel
- 代理商 R. Kody Jones
- 国际申请: PCT/EP2014/062936 WO 20140619
- 国际公布: WO2014/206855 WO 20141231
- 主分类号: C07D231/14
- IPC分类号: C07D231/14 ; C07C239/20
摘要:
The present invention relates to a process for the enantioselective preparation of the compound of formula (Ib), which process comprises a) reducing the (E)- or (Z)-form of a compound of formula (II), with an enantioselective reagent to a compound of formula (IIIa), and b) acylating the compound of formula (IIIa) with the compound of formula (IV), or c) coupling the compound of formula (IV) with the compound of formula (II), to give a compound of formula (V) and d) reducing compound of formula (V) in the presence of hydrogen, a catalyst and a chiral ligand, to the compound of formula (Ib).
公开/授权文献
信息查询