公开(公告)号：US09637457B2

公开(公告)日：2017-05-02

申请号：US14892386

申请日：2014-06-19

Applicant: Syngenta Participations AG

Inventor： Raphael Dumeunier ,  Jilali Kessabi ,  Sebastian Volker Wendeborn ,  Hannes Nussbaumer

IPC: C07D231/14 ,  C07C239/20

CPC classification number: C07D231/14 ,  C07C239/20

Abstract: The present invention relates to a process for the enantioselective preparation of the compound of formula (Ib), which process comprises a) reducing the (E)- or (Z)-form of a compound of formula (II), with an enantioselective reagent to a compound of formula (IIIa), and b) acylating the compound of formula (IIIa) with the compound of formula (IV), or c) coupling the compound of formula (IV) with the compound of formula (II), to give a compound of formula (V) and d) reducing compound of formula (V) in the presence of hydrogen, a catalyst and a chiral ligand, to the compound of formula (Ib).