A device may store a plurality of different coexistence profiles for different possible communication scenarios. The device may be initialized with a first one of the coexistence profiles, and may operate to dynamically switch to different ones of the coexistence profiles based on current conditions. Each coexistence profile may include a number of coexistence related parameters stored as a plurality of data structures. During device use, the device may dynamically select an appropriate coexistence profile based on the current communication conditions, such as Wi-Fi RSSI, Bluetooth RSSI, and/or the number of Wi-Fi and/or Bluetooth devices with which communication is currently occurring, among other possible factors. The coexistence profile is selected to provide the best possible Wi-Fi and/or Bluetooth output performance based on current conditions. The device may repeatedly dynamically select different coexistence profiles as conditions change, e.g., may select different coexistence profiles on a second or even millisecond basis.