Systems and methods for providing power savings and interference mitigation on physical transmission media are disclosed. Exemplary aspects include the ability to change physical layer (PHY) configurations based on operating conditions. By changing the PHY configuration, power consumption and electromagnetic interference (EMI) may be reduced. Still other operating conditions may be used to initiate switching between different PHYs. In another exemplary aspect, parameters of the PHY, such as slew rate, may be modified based on operating conditions to save power and/or reduce interference.