Invention Grant
- Patent Title: RORγ modulators
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Application No.: US14917420Application Date: 2014-09-08
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Publication No.: US09663469B2Publication Date: 2017-05-30
- Inventor: T. G. Murali Dhar , Jingwu Duan , Hua Gong , Bin Jiang , Zhonghui Lu , David S. Weinstein
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Elliott Korsen
- International Application: PCT/US2014/054489 WO 20140908
- International Announcement: WO2015/035278 WO 20150312
- Main IPC: C07D279/16
- IPC: C07D279/16 ; C07D401/06 ; C07D417/06 ; C07D215/58 ; C07D401/14 ; C07D401/12 ; C07D405/12 ; C07D413/12 ; C07D417/12 ; C07D491/04 ; C07D491/10 ; C07D405/14 ; C07D409/12 ; C07D471/10 ; C07D487/10 ; C07D491/044

Abstract:
Described are RORγ modulators of the formula (I), or pharmaceutically acceptable salts thereof, wherein all substituents are defined herein. The invention includes stereoisomeric forms of the compounds of formula I, including stereoisomerically-pure, scalemic and racemic form, as well as tautomers thereof. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.
Public/Granted literature
- US20160318870A1 RORy MODULATORS Public/Granted day:2016-11-03
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