Provided are systems and methods for contextual switching of microphones in audio devices. An example method includes detecting a change in conditions for capturing an acoustic signal by at least two microphones. A configuration is associated with the at least two microphones. The example method provides determining that the change in conditions has been stable for a pre-determined period of time. In response to the determination, the method changes the configuration associated with the at least two microphones. The conditions may include an absence or presence of far-end speech, reverberation, low/high signal-to-noise ratio, low/high signal-to-echo ratio, type of background noise, and so on. The changing of the configuration includes assigning a primary microphone and a secondary microphone based on a change in conditions. Based on the changed configuration, tuning parameters may be adjusted for noise suppression and acoustic echo cancellation.