Invention Grant
- Patent Title: Sublingual apomorphine
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Application No.: US14963910Application Date: 2015-12-09
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Publication No.: US09669019B2Publication Date: 2017-06-06
- Inventor: Anthony John Giovinazzo , David Bruce Hedden , Marc L. De Somer , Nathan John Bryson
- Applicant: Sunovion Pharmaceuticals Inc.
- Applicant Address: US MA Marlborough
- Assignee: Sunovion Pharmaceuticals Inc.
- Current Assignee: Sunovion Pharmaceuticals Inc.
- Current Assignee Address: US MA Marlborough
- Agency: Clark & Elbing LLP
- Agent Kristina Bieker-Brady
- Main IPC: A61F13/00
- IPC: A61F13/00 ; A61K31/485 ; A61K9/00 ; A61K9/06 ; A61K9/20 ; A61K9/70 ; A61K31/473 ; A61K47/02 ; A61K47/10 ; A61K47/18

Abstract:
Disclosed are sublingual formulations of apomorphine in unit dosage form formulated for sublingual administration, where the unit dosage form is a mucoadhesive film containing a pH neutralizing agent and apomorphine particles containing an acid addition salt of apomorphine, and where the mucoadhesive film is formed by the steps of: (i) combining a film-forming mucoadhesive polymer, apomorphine particles comprising an acid addition salt of apomorphine, and a solvent to form a mixture; and (ii) pouring the mixture onto a surface and evaporating some of the solvent to form a first film comprising the apomorphine particles, where the steps further include contacting or impregnating the first film or mixture with a pH neutralizing agent to produce the mucoadhesive film containing the apomorphine particles and the pH neutralizing agent.
Public/Granted literature
- US20160081914A1 SUBLINGUAL APOMORPHINE Public/Granted day:2016-03-24
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