A method for four dimensional reconstruction of regions exhibiting multiple phases of periodic motion includes the operation of building one or more 3-D reconstructions using a set of 2-D projections. The method further includes the operation of deriving one or more 3-D model segments from each of the one or more 3-D reconstructions, wherein a plurality of 3-D model segments are formed thereby, and wherein each of the one or more 3-D model segments is derived from a single one of the one or more 3-D model segments. The plurality of derived 3-D model segments forms a 4-D reconstruction of the region of interest.