Devices and methods for reducing or eliminating sub-pixel layout artifacts on an electronic display are provided. One such device may include an electronic display to display image data, a processor to generate the image data, and sub-pixel layout compensation circuitry that modifies the image data to reduce or eliminate a sub-pixel layout artifact of the electronic display by modifying pixels of the image data on a sub-pixel-by-sub-pixel basis. The sub-pixel layout compensation circuitry may adjust a sub-pixel of a first color in a first pixel based at least in part on a first gradient between the sub-pixel of the first color of the first pixel and a sub-pixel of the first color of a second pixel.