A cargo compartment configured to be installed in an aircraft and to accommodate a plurality of cargo receiving devices is provided. The cargo compartment surrounds a compartment interior space, and includes a floor structure arrangement having a floor surface facing the compartment interior space and configured to support cargo receiving devices loaded into the cargo compartment. The cargo compartment includes two opposite side walls extending laterally of the floor structure arrangement away from the floor surface, and the side walls include an entrance opening for access to the compartment interior space. The floor structure arrangement also includes an air cushion device having a plurality of cushion nozzles distributed in the floor surface, and the cushion nozzles are configured to blow air up from the floor surface in a direction perpendicular to the floor surface.