A self-locking glazing system includes a female profile having a first locking extension and a first leg extending therefrom, the first leg having a first tip. The system includes a male profile having a second locking extension and a second leg extending therefrom, the second leg having a second tip that is approximately opposite the first tip, and a thermal break material positioned between the female and male profiles. When a panel is positioned between the first and second tips, the female profile and the male profile are caused to engage against the thermal break material.