![Axially chiral N-(2-acylaryl)-2-[5,7-dihydro-6h-dibenzo[c,e]azepin-6-yl] acetamide compound and chirality interconversion method of a-amino acid using the same](/docs/US/2017-06-27/US09688612B2/abs.jpg.600x600.jpg)
- 专利标题： Axially chiral N-(2-acylaryl)-2-[5,7-dihydro-6h-dibenzo[c,e]azepin-6-yl] acetamide compound and chirality interconversion method of a-amino acid using the same
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申请号： US14651857申请日： 2013-12-17
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公开(公告)号： US09688612B2公开(公告)日： 2017-06-27
- 发明人: Hiroki Moriwaki , Ryosuke Takeda , Akie Kawamura , Aki Kawashima , Vadim A. Soloshonok
- 申请人： HAMARI CHEMICALS, LTD.
- 申请人地址： JP Osaka
- 专利权人： HAMARI CHEMICALS, LTD.
- 当前专利权人： HAMARI CHEMICALS, LTD.
- 当前专利权人地址： JP Osaka
- 代理机构： Wenderoth, Lind & Ponack, L.L.P.
- 优先权： JP2012-275160 20121217
- 国际申请： PCT/JP2013/083711 WO 20131217
- 国际公布： WO2014/098063 WO 20140626
- 主分类号： C07D223/14
- IPC分类号： C07D223/14 ; C07D223/18 ; C07C227/30 ; C07C319/12 ; C07D209/20 ; C07B53/00 ; C07C227/32 ; C07C229/08 ; C07C229/36 ; C07F15/04
![Axially chiral N-(2-acylaryl)-2-[5,7-dihydro-6h-dibenzo[c,e]azepin-6-yl] acetamide compound and chirality interconversion method of a-amino acid using the same](/abs-image/US/2017/06/27/US09688612B2/abs.jpg.150x150.jpg)
摘要：
An object of the present invention is to provide a method for producing an optically active amino acid in high yield and in a highly enantioselective manner, which method has fewer restrictions on the material that can be used as the substrate, and to provide, among others, a compound useful as a chiral auxiliary for the method. The present invention provides an N-(2-acylaryl)-2-[5,7-dihydro-6H-dibenzo[c,e]azepin-6-yl]acetamide compound represented by Formula (1): or a salt thereof, or a metal complex represented, by Formula (3):
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