Invention Grant
- Patent Title: Macrocyclic benzodiazepine dimers, conjugates thereof, preparation and uses
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Application No.: US15189388Application Date: 2016-06-22
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Publication No.: US09688694B2Publication Date: 2017-06-27
- Inventor: Yong Zhang , Robert M. Borzilleri , Andrew J. Tebben , Erik M. Stang , Andrew F. Donnell , Gretchen M. Schroeder , Heidi L. Perez , Donna D. Wei
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Yuan Chao
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D519/00 ; C07D498/22 ; A61K31/5513 ; A61K31/5517 ; A61K47/48 ; C07K16/30
Abstract:
Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
Public/Granted literature
- US20160376288A1 MACROCYCLIC BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, PREPARATION AND USES Public/Granted day:2016-12-29
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