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公开(公告)号：US20220306630A1
公开(公告)日：2022-09-29
申请号：US17632909
申请日：2020-08-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Lalgudi S. Harikrishnan , Peter Kinam Park , Zheming Ruan , Donna D. Wei , Daniel O'Malley , Honghe Wan , Ashok Vinayak Purandare , Brian E. Fink
IPC: C07D471/10 , C07C317/18 , C07D213/73 , C07D213/71 , C07C255/60 , C07D213/82 , C07D231/12 , C07D231/18 , C07D263/24 , C07D213/56 , C07D401/12 , C07C311/16 , C07D213/69 , C07D233/61 , C07D211/34 , C07D235/18 , C07D213/58 , C07D211/96 , C07D295/26
Abstract: The present invention is directed to compounds of the formula (I) wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US09453048B2
公开(公告)日：2016-09-27
申请号：US14419975
申请日：2013-08-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Robert M. Borzilleri , Heidi L. Perez , Donna D. Wei , Kyoung S. Kim
IPC: A61K38/06 , C07K5/09 , C07D401/12 , C07D207/16 , C07K5/062 , C07K5/083 , A61K45/06
CPC classification number: C07K5/0815 , A61K38/06 , A61K45/06 , C07D207/16 , C07D401/12 , C07K5/06026 , C07K5/0806
Abstract: There are disclosed compounds of formula (I) that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing said compounds.
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Patent Agency Ranking
公开(公告)号：US09603889B2
公开(公告)日：2017-03-28
申请号：US14432517
申请日：2013-10-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kyoung S. Kim , Liping Zhang , Donna D. Wei
CPC classification number: A61K38/08 , A61K38/00 , A61K45/06 , C07K5/0806 , C07K7/06
Abstract: There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
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公开(公告)号：US20150225452A1
公开(公告)日：2015-08-13
申请号：US14419975
申请日：2013-08-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Robert M. Borzilleri , Heidi L. Perez , Donna D. Wei , Kyoung S. Kim
CPC classification number: C07K5/0815 , A61K38/06 , A61K45/06 , C07D207/16 , C07D401/12 , C07K5/06026 , C07K5/0806
Abstract: There are disclosed compounds of formula (I) that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing said compounds.
Abstract translation: 公开了利用所述化合物调节凋亡抑制剂（IAP）的活性的式（I）化合物，含有所述化合物的药物组合物和治疗增殖性疾病的方法和失调性凋亡障碍（例如癌症）的化合物。
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公开(公告)号：US09902740B2
公开(公告)日：2018-02-27
申请号：US15606512
申请日：2017-05-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yong Zhang , Robert M. Borzilleri , Andrew J. Tebben , Erik M. Stang , Andrew F. Donnell , Gretchen M. Schroeder , Heidi L. Perez , Donna D. Wei
IPC: C07D519/00 , C07D498/22 , A61K47/48 , C07K16/30 , A61K31/5513 , A61K31/5517
CPC classification number: C07D498/22 , A61K31/5513 , A61K31/5517 , A61K47/48384 , A61K47/48569 , A61K47/48592 , A61K47/48615 , A61K47/48638 , A61K47/48715 , A61K47/6801 , A61K47/6803 , A61K47/6851 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K47/6889 , C07D519/00 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3069
Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
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公开(公告)号：US20150238558A1
公开(公告)日：2015-08-27
申请号：US14432517
申请日：2013-10-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kyoung S. Kim , Liping Zhang , Donna D. Wei
CPC classification number: A61K38/08 , A61K38/00 , A61K45/06 , C07K5/0806 , C07K7/06
Abstract: There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
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公开(公告)号：US09688694B2
公开(公告)日：2017-06-27
申请号：US15189388
申请日：2016-06-22
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yong Zhang , Robert M. Borzilleri , Andrew J. Tebben , Erik M. Stang , Andrew F. Donnell , Gretchen M. Schroeder , Heidi L. Perez , Donna D. Wei
IPC: C07D487/04 , C07D519/00 , C07D498/22 , A61K31/5513 , A61K31/5517 , A61K47/48 , C07K16/30
CPC classification number: C07D498/22 , A61K31/5513 , A61K31/5517 , A61K47/48384 , A61K47/48569 , A61K47/48592 , A61K47/48615 , A61K47/48638 , A61K47/48715 , A61K47/6801 , A61K47/6803 , A61K47/6851 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K47/6889 , C07D519/00 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3069
Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
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