Invention Grant
- Patent Title: Variant Fc-polypeptides with enhanced binding to the neonatal Fc receptor
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Application No.: US14367183Application Date: 2012-12-17
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Publication No.: US09688756B2Publication Date: 2017-06-27
- Inventor: Jeonghoon Sun , Seog Joon Han , Susie M Harris , Randal R Ketchem , Ji Lu , Mark L Michaels , Marc W Retter , Mei-Mei Tsai
- Applicant: Amgen Inc.
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Agent Raymond M. Doss
- International Application: PCT/US2012/070146 WO 20121217
- International Announcement: WO2013/096221 WO 20130627
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07K16/28 ; G01N33/68

Abstract:
Described herein are variant Fc-fragments that contain an insertion within or adjacent to a loop that bind to the neonatal Fc receptor (FcRn) with higher affinity and/or higher binding activity at pH 5-6 and approximately the same or lower affinity at a physiologic pH as compared to a control Fc-fragment, that is, little or no binding activity at a physiologic pH. Also described are variant Fc-polypeptides that comprise these variant Fc-fragments. Further described are methods of making and identifying such Fc-fragments and methods for making and using such Fc-polypeptides.
Public/Granted literature
- US20140356358A1 VARIANT FC-POLYPEPTIDES WITH ENHANCED BINDING TO THE NEONATAL FC RECEPTOR Public/Granted day:2014-12-04
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