Invention Grant
- Patent Title: Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
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Application No.: US14716767Application Date: 2015-05-19
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Publication No.: US09689006B2Publication Date: 2017-06-27
- Inventor: Mark J. Burk , Anthony P. Burgard , Priti Pharkya
- Applicant: Genomatica, Inc.
- Applicant Address: US CA San Diego
- Assignee: Genomatica, Inc.
- Current Assignee: Genomatica, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Jones Day
- Main IPC: C12P7/40
- IPC: C12P7/40 ; C12P7/46 ; C12N9/88

Abstract:
A non-naturally occurring eukaryotic or prokaryotic organism includes one or more gene disruptions occurring in genes encoding enzymes imparting increased fumarate, malate or acrylate production in the organism when the gene disruption reduces an activity of the enzyme. The one or more gene disruptions confers increased production of acrylate onto the organism. Organisms that produce acrylate have an acrylate pathway that at least one exogenous nucleic acid encoding an acrylate pathway enzyme expressed in a sufficient amount to produce acrylate, the acrylate pathway comprising a decarboxylase. Methods of producing fumarate, malate or acrylate include culturing these organisms.
Public/Granted literature
- US20160017382A1 MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF FUMARATE, MALATE, AND ACRYLATE Public/Granted day:2016-01-21
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