- 专利标题： Process for preparing hyperpolarized substrates and method for MRI
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申请号： US13639682申请日： 2011-04-08
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公开(公告)号： US09694090B2公开(公告)日： 2017-07-04
- 发明人: Silvio Aime , Giovanni Battista Giovenzana , Fabio Tedoldi , Alessandro Maiocchi , Fulvio Uggeri , Pernille Rose Jensen , Magnus Karlsson , Mathilde H. Lerche , Massimo Visigalli , Marco Crosetti , Luisa Poggi
- 申请人： Silvio Aime , Giovanni Battista Giovenzana , Fabio Tedoldi , Alessandro Maiocchi , Fulvio Uggeri , Pernille Rose Jensen , Magnus Karlsson , Mathilde H. Lerche , Massimo Visigalli , Marco Crosetti , Luisa Poggi
- 申请人地址： IT Milan
- 专利权人： BRACCO IMAGING S.P.A.
- 当前专利权人： BRACCO IMAGING S.P.A.
- 当前专利权人地址： IT Milan
- 代理机构： Vivicar Law, PLLC
- 优先权： EP10159303 20100408
- 国际申请： PCT/EP2011/055485 WO 20110408
- 国际公布： WO2011/124672 WO 20111013
- 主分类号： A61K49/10
- IPC分类号： A61K49/10 ; A61B5/05 ; A61M5/00 ; A61B5/055
摘要：
The present invention generally relates to a process for the preparation of aqueous solutions of hyperpolarized molecules ready for use in in-vivo MR diagnostic imaging, the use thereof as MRI contrast agent in investigation methods for producing diagnostic MR images of a human or non-human animal body organ, region or tissue.