- 专利标题: Heteroaryl inhibitors of sumo activating enzyme
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申请号: US14901809申请日: 2014-07-01
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公开(公告)号: US09695154B2公开(公告)日: 2017-07-04
- 发明人: Matthew O. Duffey , Dylan B. England , Zhigen Hu , Mitsuhiro Ito , Steven P. Langston , Charles McIntyre , Hirotake Mizutani , He Xu
- 申请人: MILLENNIUM PHARMACEUTICALS, INC.
- 申请人地址: US MA Cambridge
- 专利权人: Millennium Pharmaceuticals, Inc.
- 当前专利权人: Millennium Pharmaceuticals, Inc.
- 当前专利权人地址: US MA Cambridge
- 代理机构: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- 国际申请: PCT/US2014/045129 WO 20140701
- 国际公布: WO2015/002994 WO 20150108
- 主分类号: C07D239/28
- IPC分类号: C07D239/28 ; C07D401/14 ; A61K31/505 ; C07D403/06 ; A61K31/506 ; C07D401/06 ; C07D403/14 ; C07D405/14
摘要:
Disclosed are compounds of formula (I); or a pharmaceutically acceptable salt thereof; wherein Y, Ra, Ra′, Rc, Rf, X2, Rd, Rd′, Re, Re′, m, and G have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry, useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular and neurodegenerative diseases or disorders.
公开/授权文献
- US20160355504A1 HETEROARYL INHIBITORS OF SUMO ACTIVATING ENZYME 公开/授权日:2016-12-08
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