- 专利标题： Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein
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申请号： US15015161申请日： 2016-02-04
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公开(公告)号： US09695187B2公开(公告)日： 2017-07-04
- 发明人: Fabio E. S. Souza , Alena Rudolph , Ming Pan , Boris Gorin , Teng Ko Ngooi , Jason A. Bexrud , Ricardo Orprecio , Huzaifa Rangwala
- 申请人： ALPHORA RESEARCH INC.
- 申请人地址： CA Mississauga, Ontario
- 专利权人： ALPHORA RESEARCH INC.
- 当前专利权人： ALPHORA RESEARCH INC.
- 当前专利权人地址： CA Mississauga, Ontario
- 代理机构： Grossman, Tucker, Perreault & Pfleger, PLLC
- 主分类号： C07D493/22
- IPC分类号： C07D493/22 ; C07D407/14 ; C07D493/04 ; C07D307/20 ; C07C309/04
摘要：
Disclosed is a compound of formula 1, or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, R7, R7′, R8, R9, R10, R11, R12 and R13 are as disclosed herein. Also, disclosed is a process for the preparation of the compound of formula 1, or a pharmaceutically acceptable salt thereof, and intermediates used therein. The compound of formula 1 can be used in the preparation of halichondrin analogs, such as Eribulin; and a process for its preparation from the compound of formula 1 is also disclosed.