Invention Grant
- Patent Title: Genetically modified microorganism for producing long-chain dicarboxylic acid and method of using thereof
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Application No.: US14802282Application Date: 2015-07-17
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Publication No.: US09695404B2Publication Date: 2017-07-04
- Inventor: Hsin-Ju Hsieh , Liang-Jung Chien , Jia-Hung Wang , Yu-Ju Lin
- Applicant: Industrial Technology Research Institute
- Applicant Address: TW Hsinchu
- Assignee: Industrial Technology Research Institute
- Current Assignee: Industrial Technology Research Institute
- Current Assignee Address: TW Hsinchu
- Agency: Cesari and McKenna, LLP
- Priority: TW104121064A 20150630
- Main IPC: C12P7/64
- IPC: C12P7/64 ; C12N1/20 ; C12N1/00 ; C12N1/12 ; C07H21/04 ; C12N9/16 ; C12P7/44
Abstract:
Described herein are genetically-modified microorganisms for producing long-chain dicarboxylic acids and methods of using the microorganisms. The microorganisms contain a first nucleic acid encoding an Umbellularia californica lauroyl ACP-thioesterase (BTE) operably linked to a promoter or a second nucleic acid encoding a Cocos nucifera lauroyl ACP-thioesterase (FatB3) operably linked to a promoter.
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