- 专利标题： Methods of measuring levels of phosphorylated neuronal nitric oxide synthase
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申请号： US14408393申请日： 2012-12-07
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公开(公告)号： US09696309B2公开(公告)日： 2017-07-04
- 发明人: Irina Burd , Talaibek Borbiev , Elisabeth Nigrini , Michael Johnston
- 申请人： THE JOHNS HOPKINS UNIVERSITY , KENNEDY KRIEGER INSTITUTE, INC.
- 申请人地址： US MD Baltimore US MD Baltimore
- 专利权人： The Johns Hopkins University,Kennedy Krieger Institute, Inc.
- 当前专利权人： The Johns Hopkins University,Kennedy Krieger Institute, Inc.
- 当前专利权人地址： US MD Baltimore US MD Baltimore
- 代理机构： Johns Hopkins Technology Ventures
- 国际申请： PCT/US2012/068425 WO 20121207
- 国际公布： WO2013/086306 WO 20130613
- 主分类号： G01N33/535
- IPC分类号： G01N33/535 ; G01N33/573 ; G01N33/68
摘要：
The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injuries. In a specific embodiment, a method for diagnosing perinatal brain injury in a patient comprises the steps of (a) determining the ratio of phosphorylated nNOS to unphosphorylated nNOS in a sample collected from the patient using an ELISA; and (b) comparing the ratio with predefined ratios of the same proteins that correlate to a patient having perinatal brain injury and predefined ratios of the same proteins that correlate to a patient not having perinatal brain injury, wherein a correlation to one of the predefined ratios provides the diagnosis.
公开/授权文献
- US20150247854A1 BIOMARKERS FOR BRAIN INJURY 公开/授权日：2015-09-03
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