- 专利标题: β-lactamase inhibitor and process for preparing the same
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申请号: US14872988申请日: 2015-10-01
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公开(公告)号: US09708320B2公开(公告)日: 2017-07-18
- 发明人: Takao Abe , Takeshi Furuuchi , Yoshiaki Sakamaki , Seiichi Inamura , Akihiro Morinaka
- 申请人: MEIJI SEIKA PHARMA CO., LTD.
- 申请人地址: JP Tokyo
- 专利权人: MEIJI SEIKA PHARMA CO., LTD.
- 当前专利权人: MEIJI SEIKA PHARMA CO., LTD.
- 当前专利权人地址: JP Tokyo
- 代理机构: Holtz, Holtz & Volek PC
- 优先权: JP2012-122603 20120530
- 主分类号: C07D211/06
- IPC分类号: C07D211/06 ; C07D295/00 ; C07D471/08 ; C07D211/60 ; A61K45/06 ; A61K31/43 ; A61K31/545 ; A61K31/546 ; A61K31/439 ; A61K31/444 ; A61K31/4545 ; A61K31/5377 ; A61K31/437 ; A61K31/407 ; A61K31/4162 ; A61K31/427 ; C07F7/08
摘要:
A diazabicyclooctane compound, which is a beta-lactame inhibitor, represented by the following formula (I): wherein A represents Ra(Rb)N— or RcO—; B represents NH or NC1-6 alkyl; C represents benzyl, H or SO3M, wherein M represents H, an inorganic or an organic cation; Ra and Rb represent H, C1-6 alkyl or acyl; Rc represents C1-6 alkyl or a heterocyclyl; A is unsubstituted or substituted with 0 to 4 substituents Fn1, wherein Fn1 represents C1-6 alkyl, O═, or Rg-(CH2)0-3—, wherein Rg represents a heterocyclyl, phenyl, heteroaryl, acyl, RdO2S—, Re(Rf)N—, Re(Rf)NCO—, ReO—, ReOCO— or a protective group, wherein Rd represents C1-6 alkyl or MO—; Re and Rf represent H or C1-6 alkyl, and a heterocycle having at least one nitrogen atom may be formed between Ra and Rb, between Rc and B, or between Re and Rf.
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