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公开(公告)号：US10556905B2
公开(公告)日：2020-02-11
申请号：US15973861
申请日：2018-05-08
IPC分类号： C07D211/06 , C07D295/00 , C07D471/08 , A61K31/439 , A61K31/4545 , A61K31/5377 , A61K31/407 , A61K31/4162 , A61K31/427 , A61K45/06 , A61K31/43 , A61K31/545 , A61K31/546 , C07D211/60 , A61K31/444 , A61K31/437 , C07F7/08
摘要： A process for preparing a diazabicyclooctane compound represented by the following formula (I): wherein A represents RcO—; B represents NH or NC1-6 alkyl; C represents a benzyl group; Rc represents a C1-6 alkyl group; A is substituted with one substituent Fn1, wherein Fn1 represents an azetidine group; the process including: (a) silylating the compound represented by the following formula (IV-c): wherein in the formula (IV-c), OBn represents benzyloxy, and (b) carrying out an intramolecular urea formation reaction.
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公开(公告)号：US09676777B2
公开(公告)日：2017-06-13
申请号：US15007906
申请日：2016-01-27
发明人： Takao Abe , Masayuki Okue , Yoshiaki Sakamaki
IPC分类号： C07D471/08 , C07D211/60
CPC分类号： C07D471/08 , C07B2200/07 , C07D211/60
摘要： An optically active (2S,5R)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid compound defined by the following formula (F): wherein R1 represents CO2R, CO2M, or CONH2, wherein R represents an allyl group or a benzyl group, and M represents a hydrogen atom, an inorganic cation, or an organic cation; and R2 represents a benzyl group or an allyl group.
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公开(公告)号：US10000492B2
公开(公告)日：2018-06-19
申请号：US15613620
申请日：2017-06-05
IPC分类号： C07D471/08 , C07D401/12 , C07D211/60
CPC分类号： C07D471/08 , C07D211/60 , C07D401/12 , Y02P20/55
摘要： A process for producing a compound represented by a Formula (III), including reacting a compound of the following formula with a compound selected from the group consisting of 1-hydroxypyrrolidine-2,5-dione, 2-hydroxy-3a,4,7,7a-tetrahydro-1H-isoindol-1,3(2H)-dione, 2-hydroxyhexahydro-1H-isoindol-1,3(2H)-dione and 4-hydroxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione, carrying out a carbonylation to obtain a compound of the following formula removing the NH protecting group P and treating the resultant compound with a base to produce a compound represented by the following formula wherein OBn is benzyloxy and R2 is hydrogen, ClCO— or Cl3COCO—.
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公开(公告)号：US10000491B2
公开(公告)日：2018-06-19
申请号：US15023976
申请日：2014-09-24
IPC分类号： C07D471/08 , C07D401/12 , C07D211/60
CPC分类号： C07D471/08 , C07D211/60 , C07D401/12 , Y02P20/55
摘要： A process for producing a diazabicyclooctane derivative represented by Formula (IV) and intermediates thereof by carrying out the following steps: wherein P is an NH protecting group capable of being removed with acid; R1 is 2,5-dioxopyrrolidin-1-yl, 1,3-dioxo-3a,4,7,7a-tetrahydro-1H-isoindol-2(3H)-yl, 1,3-dioxohexahydro-1H-isoindol-2(3H)-yl, or 3,5-dioxo-4-azatricyclo[5.2.1.02.6]dec-8-en-4-yl; R2 is hydrogen, ClCO— or Cl3COCO—; R3 is C1-6 alkyl or heterocyclyl, or forms a 3- to 7-membered heterocyclic ring together with the —O—NH— to which it is attached; and OBn is benzyloxy.
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5.发明授权Compounds useful for producing an optically active diazabicyclooctane compound 有权可用于制备光学活性二氮杂双环辛烷化合物的化合物公开(公告)号：US09284273B2
公开(公告)日：2016-03-15
申请号：US14676179
申请日：2015-04-01
发明人： Takao Abe , Masayuki Okue , Yoshiaki Sakamaki
IPC分类号： C07D211/06 , C07D211/60 , C07D471/08
CPC分类号： C07D471/08 , C07B2200/07 , C07D211/60
摘要： A compound of the following compound (B): wherein tBu represents a tert-butyl group. A compound of the following compound (C): wherein tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group.
摘要翻译： 下列化合物（B）的化合物：其中tBu表示叔丁基。 下列化合物（C）的化合物：其中tBu表示叔丁基，TFA表示三氟乙酰基。
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公开(公告)号：US11117896B2
公开(公告)日：2021-09-14
申请号：US16660682
申请日：2019-10-22
IPC分类号： C07D471/08 , C07D211/60 , A61K31/437 , A61K31/444 , A61K31/546 , A61K31/43 , A61K31/439 , A61K31/4545 , A61K31/5377 , A61K31/407 , A61K31/4162 , A61K31/427 , A61K45/06 , A61K31/545 , C07F7/08
摘要： A process for preparing a diazabicyclooctane compound represented by the following formula (I): wherein A represents RcO—; B represents NH or NC1-6 alkyl; C represents a benzyl group; Rc represents a C1-6 alkyl group; A is substituted with one substituent Fn1, wherein Fn1 represents an azetidine group; the process including: (a) silylating the compound represented by the following formula (IV-c): wherein in the formula (IV-c), OBn represents benzyloxy, and (b) carrying out an intramolecular urea formation reaction.
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公开(公告)号：US10604522B2
公开(公告)日：2020-03-31
申请号：US16148774
申请日：2018-10-01
IPC分类号： A61K31/439 , C07D471/08 , A61K45/06
摘要： A process for producing a compound of the following Formula (VII-CR): The process involving providing a compound represented by the following Formula (VI): in a case where the R3ONHC(═O) side chain in the compound of the Formula (VI) has a protecting group, removing the protecting group from the compound of the Formula (VI) with an acid, and adding an ester-based poor solvent to the resultant reaction solution to precipitate the compound of Formula (VII-CR), wherein in the compounds of the Formulas (VII-CR) and (VI), R3 is a C1-6 alkyl or a heterocycle.
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公开(公告)号：US10131665B2
公开(公告)日：2018-11-20
申请号：US15027956
申请日：2014-10-08
IPC分类号： C07D471/08 , A61K31/439 , A61K45/06
摘要： A crystalline form of a diazabicyclooctane derivative represented by the following Formula (VII), and processes for producing the same:
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公开(公告)号：US12103928B2
公开(公告)日：2024-10-01
申请号：US18199019
申请日：2023-05-18
发明人： Takao Abe , Takeshi Furuuchi , Yoshiaki Sakamaki
IPC分类号： C07D471/08 , A61K31/407 , A61K31/4162 , A61K31/427 , A61K31/43 , A61K31/437 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/545 , A61K31/546 , A61K45/06 , C07D211/60 , C07F7/08
CPC分类号： C07D471/08 , A61K31/407 , A61K31/4162 , A61K31/427 , A61K31/43 , A61K31/437 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/545 , A61K31/546 , A61K45/06 , C07D211/60 , C07F7/0812 , Y02P20/55 , A61K31/43 , A61K2300/00 , A61K31/545 , A61K2300/00 , A61K31/546 , A61K2300/00 , A61K31/407 , A61K2300/00 , A61K31/4162 , A61K2300/00 , A61K31/427 , A61K2300/00 , A61K31/439 , A61K2300/00 , A61K31/4545 , A61K2300/00 , A61K31/5377 , A61K2300/00
摘要： A process for preparing a diazabicyclooctane compound represented by the following formula (I):
wherein A represents RcO—; B represents NH or NC1-6 alkyl; C represents a benzyl group; Rc represents a C1-6 alkyl group; A is substituted with one substituent Fn1, wherein Fn1 represents an azetidine group; the process including: (a) silylating the compound represented by the following formula (IV-c):
wherein in the formula (IV-c), OBn represents benzyloxy, and (b) carrying out an intramolecular urea formation reaction.-
公开(公告)号：US11414417B2
公开(公告)日：2022-08-16
申请号：US16793843
申请日：2020-02-18
IPC分类号： C07D471/08 , A61K31/439 , A61K45/06
摘要： A crystalline form I of a compound represented by Formula (VII-1): having characteristic peaks appearing at lattice spacing (d) of 7.34, 5.66, 5.53, 5.30, 5.02, 4.66, 4.37, 4.28, 4.06, 3.68, 3.62, 3.47, 3.36, 3.30, 3.16, 3.11, 3.03, 2.99 and 2.50 Å in the powder X-ray diffraction pattern.
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