Invention Grant
- Patent Title: Macrocyclic compounds as Trk kinase inhibitors
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Application No.: US15401839Application Date: 2017-01-09
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Publication No.: US09718822B2Publication Date: 2017-08-01
- Inventor: Steven W. Andrews , Kevin Ronald Condroski , Julia Haas , Yutong Jiang , Gabrielle R. Kolakowski , Jeongbeob Seo , Hong-Woon Yang , Qian Zhao
- Applicant: Array BioPharma, Inc.
- Applicant Address: US CO Boulder
- Assignee: Array BioPharma, Inc.
- Current Assignee: Array BioPharma, Inc.
- Current Assignee Address: US CO Boulder
- Agency: Fish & Richardson P.C.
- Main IPC: C07D487/22
- IPC: C07D487/22 ; A61K31/519 ; C07D471/22 ; C07D498/22
Abstract:
Compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
Public/Granted literature
- US20170114059A1 MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS Public/Granted day:2017-04-27
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