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![Method of treatment using substituted pyrazolo[1,5-a] pyrimidine compounds](/abs-image/US/2022/03/08/US11267818B2/abs.jpg.150x150.jpg)
公开(公告)号：US11267818B2
公开(公告)日：2022-03-08
申请号：US17020461
申请日：2020-09-14
申请人： Array BioPharma Inc.
发明人： Julia Haas , Steven W. Andrews , Yutong Jiang , Gan Zhang
IPC分类号： C07D487/04 , C07D471/04 , C07D519/00 , A61P29/00 , A61K9/00 , A61K31/519 , A61K31/5377 , A61K45/06
摘要： Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.
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公开(公告)号：US10647715B2
公开(公告)日：2020-05-12
申请号：US16412091
申请日：2019-05-14
发明人： Matthew Arnold Marx , Thomas P. Bobinski , Aaron Craig Burns , John Gaudino , Julia Haas , John Michael Ketcham , John David Lawson , Brad Newhouse , Spencer Pajk , Christopher Ronald Smith , Tony P. Tang
IPC分类号： C07D471/04 , A61P35/00 , C07D519/00
摘要： The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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3.发明申请公开(公告)号：US20190270749A1
公开(公告)日：2019-09-05
申请号：US16415575
申请日：2019-05-17
申请人： Array BioPharma Inc.
发明人： Shelley Allen , Steven Wade Andrews , James F. Blake , Barbara J. Brandhuber , Julia Haas , Yutong Jiang , Timothy Kercher , Gabrielle R. Kolakowski , Allen A. Thomas , Shannon L. Winski
IPC分类号： C07D491/048 , C07D409/14 , C07D401/14 , C07D231/52 , C07D231/56 , C07D401/04 , C07D453/02 , C07D413/12 , C07D405/12 , C07D403/14 , C07D403/04 , C07D403/02 , C07D401/12 , C07D231/54 , C07D231/40 , C07D405/14 , C07D471/08
摘要： Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
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公开(公告)号：US20190247398A1
公开(公告)日：2019-08-15
申请号：US16170976
申请日：2018-10-25
发明人： Qian Zhao , Stacey Spencer , Yutong Jiang , Julia Haas , Charles Todd Eary
IPC分类号： A61K31/519 , A61P35/00
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/0095 , A61K31/404 , A61K31/496 , A61K47/02 , A61K47/36 , A61K47/38 , A61P35/00 , C07B2200/13 , C07C55/06 , C07C55/10 , C07C57/145 , C07C57/15 , C07C59/08 , C07C59/245 , C07C59/255 , C07C59/265 , C07C59/285 , C07C63/06 , C07C229/24 , C07C233/83 , C07C301/00 , C07C309/04 , C07C309/05 , C07C309/08 , C07C309/29 , C07C309/30 , C07C309/35 , C07D471/22 , A61K2300/00
摘要： The present application in some embodiments provides a pharmaceutical composition comprising: and a compounding agent. Further provided herein are methods of making and methods of using the pharmaceutical compositions, for example, in the treatment of cancer.
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公开(公告)号：US10323022B2
公开(公告)日：2019-06-18
申请号：US15839706
申请日：2017-12-12
申请人： Array BioPharma Inc.
发明人： Shelley Allen , Steven W. Andrews , James F. Blake , Kevin R. Condroski , Julia Haas , Lily Huang , Yutong Jiang , Timothy Kercher , Gabrielle R. Kolakowski , Jeongbeob Seo
IPC分类号： C07D403/12 , A61K31/4162 , A61K31/4155 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , A61K31/4178 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4375 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , C07D491/048
摘要： Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Y, B, and Ring C are as defined herein, and wherein the Y—B moiety and the NH—C(═X)—NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
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公开(公告)号：US20190076437A1
公开(公告)日：2019-03-14
申请号：US16199875
申请日：2018-11-26
申请人： Array BioPharma Inc.
IPC分类号： A61K31/529 , A61K31/675 , A61K31/4545 , A61K31/496 , A61P35/00
摘要： Methods for inhibiting a ROS1 kinase with compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein. The compounds and methods provided herein are useful in the treatment of cancer (e.g., ROS1-associated cancers as defined herein).
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公开(公告)号：US20190076436A1
公开(公告)日：2019-03-14
申请号：US16199867
申请日：2018-11-26
申请人： Array BioPharma Inc.
IPC分类号： A61K31/529 , A61K31/675 , A61K31/4545 , A61P35/00
摘要： Methods for inhibiting a ROS1 kinase with compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein. The compounds and methods provided herein are useful in the treatment of cancer (e.g., ROS1-associated cancers as defined herein).
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![Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors](/abs-image/US/2019/01/08/US10174027B2/abs.jpg.150x150.jpg)
公开(公告)号：US10174027B2
公开(公告)日：2019-01-08
申请号：US15858658
申请日：2017-12-29
发明人： Steven W. Andrews , James F. Blake , Mark J. Chicarelli , Adam Golos , Julia Haas , Yutong Jiang , Gabrielle R. Kolakowski
IPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/499 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D519/00
摘要： Provided herein are compounds of the General Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X1, X2, X3 and X4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including diseases or disorders mediated by a RET kinase.
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![SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS](/abs-image/US/2018/05/17/US20180133207A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180133207A1
公开(公告)日：2018-05-17
申请号：US15860894
申请日：2018-01-03
发明人： Steven W. Andrews , Sean Aronow , James F. Blake , Barbara J. Brandhuber , James Collier , Adam Cook , Julia Haas , Yutong Jiang , Gabrielle R. Kolakowski , Elizabeth A. McFaddin , Megan L. McKenney , Oren T. McNulty , Andrew T. Metcalf , David A. Moreno , Ginelle A. Ramann , Tony P. Tang , Li Ren , Shane M. Walls
IPC分类号： A61K31/4545 , A61K45/06 , A61P35/00 , A61P35/02 , A61K31/444 , A61K31/506 , A61K31/501 , A61K31/497 , A61K31/5377
CPC分类号： A61K31/4545 , A61K31/4162 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , A61P1/00 , A61P1/12 , A61P35/00 , A61P35/02 , C07D471/04
摘要： Provided herein are compounds of the Formula I: or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
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公开(公告)号：US09902741B2
公开(公告)日：2018-02-27
申请号：US15632187
申请日：2017-06-23
发明人： Steven W. Andrews , Kevin Ronald Condroski , Julia Haas , Yutong Jiang , Gabrielle R. Kolakowski , Jeongbeob Seo , Hong-Woon Yang , Qian Zhao
IPC分类号： C07D498/22 , C07D471/22 , C07D487/22
CPC分类号： C07D498/22 , A61K31/519 , C07D471/22 , C07D487/04 , C07D487/22 , C07D519/00
摘要： Compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
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