发明授权
- 专利标题： 5′-end derivatives
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申请号： US13696796申请日： 2011-04-22
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公开(公告)号： US09725479B2公开(公告)日： 2017-08-08
- 发明人: Muthiah Manoharan , Kallanthottathil G. Rajeev , Ivan Zlatev , Eric E. Swayze , Thazha P. Prakash , Walter F. Lima
- 申请人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Ivan Zlatev , Eric E. Swayze , Thazha P. Prakash , Walter F. Lima
- 申请人地址： US CA Carlsbad US MA Cambridge
- 专利权人： Ionis Pharmaceuticals, Inc.,Alaylam Pharmacueuticals, Inc.
- 当前专利权人： Ionis Pharmaceuticals, Inc.,Alaylam Pharmacueuticals, Inc.
- 当前专利权人地址： US CA Carlsbad US MA Cambridge
- 代理机构： Ionis Patent Department
- 国际申请： PCT/US2011/033592 WO 20110422
- 国际公布： WO2011/133871 WO 20111027
- 主分类号： C07H17/02
- IPC分类号： C07H17/02 ; C07H19/067 ; C07H21/02 ; C12N15/113
摘要：
The present invention provides compounds of formula (1). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
公开/授权文献
- US20130323836A1 5'-END DERIVATIVES 公开/授权日：2013-12-05
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