Invention Grant
- Patent Title: Bicyclic heterocyclic compound containing a substituted pyrrole ring
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Application No.: US14443598Application Date: 2013-11-18
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Publication No.: US09732086B2Publication Date: 2017-08-15
- Inventor: Takahiro Sugimoto , Minoru Nakamura , Hiroki Sakamoto , Shinkichi Suzuki , Masami Yamada , Makoto Kamata , Takuto Kojima , Ikuo Fujimori , Kenichiro Shimokawa
- Applicant: Takeda Pharmaceutical Company Limited
- Applicant Address: JP Osaka
- Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee Address: JP Osaka
- Agency: Hamre, Schumann, Mueller & Larson, P.C.
- Priority: JP2012-253708 20121119
- International Application: PCT/JP2013/081084 WO 20131118
- International Announcement: WO2014/077401 WO 20140522
- Main IPC: C07D221/02
- IPC: C07D221/02 ; A61K31/44 ; C07D487/04 ; C07D401/14 ; C07D405/14 ; C07D401/06 ; C07D403/10 ; C07D403/14 ; C07D405/12 ; C07D409/14 ; C07D413/12 ; C07D417/12 ; C07D453/02 ; C07D471/04 ; C07D471/14 ; C07D209/46 ; C07D519/00

Abstract:
Provided is a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, and useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder and the like. The present invention relates to a compound represented by the formula wherein ring A is a 4- to 7-membered ring optionally having substituent(s); L is —O—, —S—, —SO— or —SO2—; R1 is a C1-6 alkyl group optionally having substituent(s) (provided that when L is —O—, R1 is not a C1-6 alkyl group optionally substituted by halogen atom(s)), or a cyclic group optionally having substituent(s); X1 is —CRa═ or —N═; X2 is —CRb═ or —N═; X3 is —CRc= or —N═; Ra, Rb and Rc are each a C1-6 alkyl group, C2-6 alkenyl group, C1-6 alkoxy group, C3-6 cycloalkyl group, C3-6 cycloalkoxy group or C6-14 aryl group, each of which optionally having substituent(s), H or halogen, or a salt thereof.
Public/Granted literature
- US09777005B2 Bicyclic heterocyclic compound containing a substituted pyrrole ring Public/Granted day:2017-10-03
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