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公开(公告)号：US10457670B2
公开(公告)日：2019-10-29
申请号：US15830634
申请日：2017-12-04
发明人： Masami Yamada , Shinkichi Suzuki , Takahiro Sugimoto , Minoru Nakamura , Hiroki Sakamoto , Makoto Kamata
IPC分类号： C07D405/14 , C07D405/04 , C07D209/46 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , A61K31/145 , A61K31/325 , A61K31/4035 , A61K31/4155 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/55 , C07D471/04 , C07D403/10 , A61K31/13 , A61K31/045
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like.The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the specification, or a salt thereof.
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公开(公告)号：US20180346452A1
公开(公告)日：2018-12-06
申请号：US15830634
申请日：2017-12-04
发明人： Masami YAMADA , Shinkichi Suzuki , Takahiro Sugimoto , Minoru Nakamura , Hiroki Sakamoto , Makoto Kamata
IPC分类号： C07D405/14 , C07D405/04 , A61K31/045 , C07D403/10 , C07D403/04 , C07D401/14 , C07D401/10 , C07D401/06 , C07D209/46 , A61K31/55 , A61K31/445 , A61K31/4439 , A61K31/4406 , A61K31/4155 , A61K31/4035 , A61K31/325 , A61K31/13 , C07D471/04
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like.The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the specification, or a salt thereof.
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公开(公告)号：US09775827B2
公开(公告)日：2017-10-03
申请号：US15488002
申请日：2017-04-14
发明人： Masami Yamada , Shinkichi Suzuki , Takahiro Sugimoto , Minoru Nakamura , Hiroki Sakamoto , Makoto Kamata
IPC分类号： C07D209/46 , C07D403/10 , C07D405/14 , C07D403/04 , C07D401/10 , C07D401/14 , A61K31/4035 , A61K31/445 , A61K31/55 , A61K31/325 , A61K31/4155 , A61K31/4439
CPC分类号： C07D405/14 , A61K31/045 , A61K31/13 , A61K31/325 , A61K31/4035 , A61K31/4155 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/55 , C07D209/46 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D471/04
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like.The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the specification, or a salt thereof.
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公开(公告)号：US10548899B2
公开(公告)日：2020-02-04
申请号：US15769295
申请日：2016-10-19
发明人： Takahiro Sugimoto , Shinkichi Suzuki , Hiroki Sakamoto , Masami Yamada , Minoru Nakamura , Makoto Kamata , Kenichiro Shimokawa , Masaki Ogino , Eiji Kimura , Masataka Murakami , Takuto Kojima , Jinichi Yonemori
IPC分类号： A61K31/53 , A61K31/517 , C07D403/06 , C07D403/10 , C07D405/14 , C07D401/14 , C07D239/88 , C07D401/06 , A61P25/28 , A61P25/04 , A61P25/18 , A61P25/16
摘要： The present invention provides a compound which has a cholinergic muscarinic M1 receptor positive allosteric modulator activity and may be useful as a medicament such as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, Lewy body dementia and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof. In the formula (I), each symbol is as described in the attached specification.
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公开(公告)号：US09732086B2
公开(公告)日：2017-08-15
申请号：US14443598
申请日：2013-11-18
发明人： Takahiro Sugimoto , Minoru Nakamura , Hiroki Sakamoto , Shinkichi Suzuki , Masami Yamada , Makoto Kamata , Takuto Kojima , Ikuo Fujimori , Kenichiro Shimokawa
IPC分类号： C07D221/02 , A61K31/44 , C07D487/04 , C07D401/14 , C07D405/14 , C07D401/06 , C07D403/10 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04 , C07D471/14 , C07D209/46 , C07D519/00
摘要： Provided is a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, and useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder and the like. The present invention relates to a compound represented by the formula wherein ring A is a 4- to 7-membered ring optionally having substituent(s); L is —O—, —S—, —SO— or —SO2—; R1 is a C1-6 alkyl group optionally having substituent(s) (provided that when L is —O—, R1 is not a C1-6 alkyl group optionally substituted by halogen atom(s)), or a cyclic group optionally having substituent(s); X1 is —CRa═ or —N═; X2 is —CRb═ or —N═; X3 is —CRc= or —N═; Ra, Rb and Rc are each a C1-6 alkyl group, C2-6 alkenyl group, C1-6 alkoxy group, C3-6 cycloalkyl group, C3-6 cycloalkoxy group or C6-14 aryl group, each of which optionally having substituent(s), H or halogen, or a salt thereof.
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公开(公告)号：US09499516B2
公开(公告)日：2016-11-22
申请号：US15013625
申请日：2016-02-02
发明人： Masami Yamada , Shinkichi Suzuki , Takahiro Sugimoto , Minoru Nakamura , Hiroki Sakamoto , Makoto Kamata
IPC分类号： C07D209/46 , C07D403/10 , C07D405/14 , C07D403/04 , C07D401/10 , C07D401/14 , C07D401/06 , C07D405/04
CPC分类号： C07D405/14 , A61K31/045 , A61K31/13 , A61K31/325 , A61K31/4035 , A61K31/4155 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/55 , C07D209/46 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D471/04
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like.The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the specification, or a salt thereof.
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公开(公告)号：US20150126487A1
公开(公告)日：2015-05-07
申请号：US14382390
申请日：2013-02-28
发明人： Hiroki Sakamoto , Takahiro Sugimoto
IPC分类号： C07D405/12 , C07D401/10 , C07D401/12 , C07D401/06 , C07D237/28 , C07D215/56 , C07D403/10
CPC分类号： C07D405/12 , C07D215/56 , C07D237/28 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/10
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, and useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, a sleep disorder and the like. The present invention relates to a compound represented by the formula (I): wherein R1 is an optionally substituted amino group or an optionally substituted cyclic amino group, R2 and R3 are each independently a hydrogen atom or a substituent, X is —CH═ or —N═, and ring A is an optionally substituted 5- to 10-membered ring, or a salt thereof.
摘要翻译： 本发明提供具有胆碱能毒蕈碱M1受体阳性变构调节剂活性的化合物，可用作阿尔茨海默氏病，精神分裂症，疼痛，睡眠障碍等的预防或治疗药物。 本发明涉及由式（I）表示的化合物：其中R 1为任选取代的氨基或任意取代的环状氨基，R 2和R 3各自独立地为氢原子或取代基，X为-CH =或 -N =，环A为任选取代的5至10元环或其盐。
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8.发明授权公开(公告)号：US10899752B2
公开(公告)日：2021-01-26
申请号：US16394762
申请日：2019-04-25
发明人： Takahiro Sugimoto , Shinkichi Suzuki , Hiroki Sakamoto , Masami Yamada , Minoru Nakamura , Makoto Kamata , Kenichiro Shimokawa , Masataka Murakami , Jinichi Yonemori , Takuto Kojima
IPC分类号： C07D413/14 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/06 , C07D471/04 , C07D491/107 , C07D265/22 , C07F7/02 , A61P25/28 , C07D417/10 , C07F7/08
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, which may be useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof: wherein each symbol is as defined in the attached DESCRIPTION.
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公开(公告)号：US20200247747A1
公开(公告)日：2020-08-06
申请号：US16777273
申请日：2020-01-30
发明人： Yasushi Hattori , Yuhei Miyanohana , Yuichi Kajita , Tatsuki Koike , Yasutaka Hoashi , Norihito Tokunaga , Alexander Martin Pawliczek , Tsuneo Oda , Tohru Miyazaki , Yoshiteru Ito , Kohei Takeuchi , Keisuke Imamura , Takahiro Sugimoto
IPC分类号： C07D207/14 , C07D417/06 , C07D407/08
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.
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公开(公告)号：US10428023B2
公开(公告)日：2019-10-01
申请号：US16052967
申请日：2018-08-02
发明人： Yuichi Kajita , Yuhei Miyanohana , Tatsuki Koike , Kohei Takeuchi , Yoshiteru Ito , Norihito Tokunaga , Takahiro Sugimoto , Tohru Miyazaki , Tsuneo Oda , Yasutaka Hoashi , Yasushi Hattori , Keisuke Imamura
IPC分类号： C07D211/56 , A61P25/00 , C07D205/04 , C07D207/14 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/10 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/14 , C07D405/06 , C07D211/36
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.
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