- 专利标题： Neutralizing antibodies to HIV-1 and their use
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申请号： US14864705申请日： 2015-09-24
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公开(公告)号： US09738703B2公开(公告)日： 2017-08-22
- 发明人: John Mascola , Richard Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary Nabel , Peter Kwong , Tongqing Zhou , Mark Connors , William Schief
- 申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , University of Washington
- 申请人地址： US DC Washington US WA Seattle
- 专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services,University of Washington
- 当前专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services,University of Washington
- 当前专利权人地址： US DC Washington US WA Seattle
- 代理机构： Klarquist Sparkman, LLP
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/00 ; C07K16/10 ; A61K38/00 ; C07H21/04 ; A61K39/42 ; A61K45/06
摘要：
Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
公开/授权文献
- US20160009789A1 NEUTRALIZING ANTIBODIES TO HIV-1 AND THEIR USE 公开/授权日：2016-01-14
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