- 专利标题: Triple quadrupole mass spectrometry coupled to trapped ion mobility separation
-
申请号: US14978508申请日: 2015-12-22
-
公开(公告)号: US09741552B2公开(公告)日: 2017-08-22
- 发明人: Melvin Andrew Park , Mark Ridgeway , Desmond Allen Kaplan , Felician Muntean
- 申请人: Bruker Daltonics, Inc.
- 代理机构: Benoît & Côté Inc.
- 主分类号: H01J49/42
- IPC分类号: H01J49/42 ; H01J49/10
摘要:
The invention provides a method for acquiring fragment ion spectra of substances in complex substance mixtures wherein a trapped ion mobility spectrometer (“TIMS”) is used as the ion mobility separation device coupled to a triple quadrupole mass filter assembly. The fragment ion spectra may be used for the identification of high numbers of proteins in complex mixtures, or for a safe quantification of some substances, by their fragment ion mass spectra in a mass spectrometer with upstream substance separator. TIMS, in particular equipped with parallel accumulation, provides the unique possibility to prolong the ion accumulation duration to find more detectable ion species without decreasing the measuring capacity for fragment ion mass spectra. The high measurement capacity for fragment ion mass spectra permits the repeated measurement of low abundance ion species such as to improve the quality of the fragment ion spectra.
公开/授权文献
信息查询