Systems and methods for automatically configuring a distributed antenna system are provided. A configuration sub-system of the distributed antenna system can identify signal parameters for downlink signals received from one or more base stations via inputs of a unit in the distributed antenna system. The configuration sub-system can automatically determine a configuration plan for the distributed antenna system based on the automatically identified signal parameters. The configuration plan specifies how to combine subsets of the downlink signals for routing to remote antenna units of the distributed antenna system.