Clock timing skew may occur during operation of a time-interleaved receiver. It would be beneficial to try to determine if there is timing skew, and if there is, then address it, such as by reducing or eliminating some or all of the timing skew. Embodiments are described herein that may achieve this. In one embodiment, a method includes generating at least two clocks having the same frequency but a different phase. Intersymbol interference (ISI) values are then determined, one for each of the clocks, by: for each clock, sampling a signal using the clock and determining a value representing ISI based on the sampled signal. A clock phase of at least one of the clocks is adjusted in response to at least one of the ISI values being different from a reference ISI value.