Active noise reduction (ANR) headphones and associated methods are provided. The ANR headphones may include a memory to store a plurality of profiles each including controller information and acoustic parameters in addition to a profile selection routine executable by a processor of the ANR headphone. The profile selection routine may be configured to identify acoustic characteristics of a subject wearing the ANR headphone, compare the acoustic characteristics of the subject with the acoustic parameters of the plurality of profiles, select a profile from the plurality of profiles based on the comparison between the acoustic characteristics of the subject with the acoustic parameters of the selected profile, and provide the controller information of the selected profile to a noise reduction circuit of the ANR headphone.