A method includes determining a change in a volume of a tissue of interest located in at least two data sets between the at least two data sets. The at least two image data sets include a first image data set acquired at a first time and a second image data set acquired at a second time, and the first and second times are different. The method includes generating a rendering which includes a region in which the tissue of interest is located and indicia that indicates a magnitude of the change across the region. The region is superimposed over the rendering, which is generated based on at least one of the at least two image data sets, and linked to a corresponding image respectively in the at least two image data sets including voxels representing tissue of interest. The method includes visually presenting the rendering in a graphical user interface.