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公开(公告)号：US10729340B2
公开(公告)日：2020-08-04
申请号：US14782605
申请日：2014-04-09
发明人： Tobias Klinder , Holger Schmitt , Michael Grass
IPC分类号： A61B5/026 , G16H40/63 , A61B5/02 , G16H50/50 , G16H30/40 , A61B5/06 , A61B17/00 , A61B90/00 , A61B8/12 , A61B5/107 , A61B5/00 , A61B8/08 , A61B34/20 , A61B34/10 , A61B8/00
摘要： A medical system includes a medical instrument (102) configured for interventional deployment and a shape sensing system (104) mounted on or in the medical instrument and configured to measure a shape of the medical instrument during the interventional deployment. An imaging device (106) is mounted on or in the medical instrument and configured to image a lumen in which the imaging device is deployed. A registration module (140) is configured to register the shape of the medical instrument to an image of the lumen at a particular time to reconstruct a three-dimensional geometry of the lumen, accounting for motion.
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公开(公告)号：US10552958B2
公开(公告)日：2020-02-04
申请号：US15570620
申请日：2016-04-26
发明人： Eberhard Sebastian Hansis , Holger Schmitt , Michael Grass , Dirk Schaefer , Hanno Heyke Homann , Tobias Klinder , Christian Haase
IPC分类号： G06K9/00 , G06T7/00 , G06T17/20 , A61B5/0215 , A61B5/026 , A61B5/00 , A61B6/03 , A61B6/00 , G06T7/60
摘要： The present invention relates to a device (1) for fractional flow reserve determination, the device (1) comprising: a model source (10) configured to provide a first three-dimensional model (3DM1) of a portion of an imaged vascular vessel tree (VVT) surrounding a stenosed vessel segment (SVS) and configured to provide a second three-dimensional model (3DM2) of a pressure wire insertable into the vascular vessel tree (VVT); and a processor (20) configured to calculate a first blood flow (Q1) through the stenosed vessel segment (SVS) with the pressure wire (PW) inserted into the vascular vessel tree (VVT) based on the first and the second three-dimensional model and to calculate a second blood flow (Q2) through the stenosed vessel segment (SVS) without the pressure wire (PW) inserted into the vascular vessel tree (VVT) based on the first three-dimensional model (3DM1) and to determine a first fractional flow reserve value (FFR1) to be measured with the pressure wire (PW) inserted into the vascular vessel tree (VVT) based on the first blood flow (Q1) and to determine a second fractional flow reserve value (FFR2) to be measured without the pressure wire (PW) inserted into the vascular vessel tree (VVT) based on the second blood flow (Q1).
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公开(公告)号：US10290102B2
公开(公告)日：2019-05-14
申请号：US14405007
申请日：2013-06-18
发明人： Cristian Lorenz , Sven Kabus , Tobias Klinder , Jens Von Berg
摘要： An image registration apparatus (118) includes an image quality driven image registration determiner (202) that determines an image quality driven image registration for a set of images to register based on a non-rigid registration (204), which includes an optimization of an image similarity term and a regularization term, and a registration steering factor, and a registration component (206) that registers the set of images using the image quality driven image registration. A method determining an image quality driven image registration for a set of images to register based on a non-rigid registration, which includes an optimization of an image similarity term and a regularization term, and a registration steering factor, and registering the set of images using the fidelity driven image registration, generating a set of registered images.
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公开(公告)号：US10074207B2
公开(公告)日：2018-09-11
申请号：US15304932
申请日：2015-05-19
发明人： Rafael Wiemker , Tobias Klinder , Thomas Buelow
CPC分类号： G06T15/06 , G06T7/0012 , G06T7/187 , G06T15/08 , G06T19/20 , G06T2207/10072 , G06T2207/10081 , G06T2207/30101 , G06T2210/41 , G06T2219/2008
摘要： A method includes obtaining contrast-enhanced image data having a plurality of voxels, each voxel having an intensity value. The method further includes determining a vesselness value for each voxel. The method further includes determining a hypo-density value for each voxel. The method further includes weighting each of the intensity values by a corresponding vesselness value. The method further includes weighting each of the hypo-density values by the corresponding vesselness value. The method further includes combining the weighted intensity values and the weighted hypo-density values, thereby generating composite image data. The method further includes visually displaying the composite image data.
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公开(公告)号：US11410305B2
公开(公告)日：2022-08-09
申请号：US16967446
申请日：2019-02-01
发明人： Rafael Wiemker , Jörg Sabczynski , Tobias Klinder
摘要： Iterative material decomposition of multispectral image data includes providing a plurality of spectral images of a region of interest comprising a body part and a plurality of sets of material coefficients for a plurality of materials. Each spectral image is decomposed into a plurality of material images and an offset image. At least one of the material images for each spectral image is manipulated on the basis of at least one topological constraint relating to the body part to determine for each spectral image an updated plurality of material images and an updated offset image. A plurality of spectral images is then recomposed from the corresponding updated plurality of material images and the updated offset. Intensities at image locations are compared, and the updated plurality of material images is modified. The steps are repeated until convergence, and at least one of the recomposed spectral images at convergence is output.
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公开(公告)号：US11042987B2
公开(公告)日：2021-06-22
申请号：US16606249
申请日：2018-04-18
摘要： A method for modelling a composition of an object of interest comprises segmenting object of interest image data provided by computer tomography image data resulting in a plurality of image segments. A determined Hounsfield density value is then extracted from the object of interest image data for each image segment. A component ratio of at least two component classes is defined for the object of interest, the at least two component classes having different component Hounsfield density values. At least one component class is assigned to each image segment based on the corresponding determined Hounsfield density value resulting in simulated image segments comprising the component Hounsfield density values. The simulated image segments define simulated image data of the object of interest, where a ratio of the assigned component classes corresponds to the component ratio. A deviation between the simulated image data and the object of interest image data is then determined.
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公开(公告)号：US10902606B2
公开(公告)日：2021-01-26
申请号：US16060453
申请日：2016-12-19
摘要： A system (100) for segmenting a coronary artery vessel tree (182) of a patient heart in a three dimensional (3D) cardiac image (120) includes a coronary volume definition unit (150) and a coronary artery segmentation unit (180). The coronary volume definition unit (150) sets a spatial boundary (210, 220) from internal and external surfaces of heart tissues in the 3D cardiac image based on a fitted heart model (200). The coronary artery segmentation unit (180) segments the coronary artery vessel tree (182) in the 3D cardiac image using a segmentation algorithm with a search space limited by the spatial boundary set from the internal and external surfaces of the heart tissues.
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公开(公告)号：US10758212B2
公开(公告)日：2020-09-01
申请号：US14361884
申请日：2012-11-28
发明人： Rafael Wiemker , Kongkuo Lu , Sheng Xu , Tobias Klinder , Martin Bergtholdt
IPC分类号： A61B10/02 , G06F3/0481 , G06F3/0484 , G06T19/00 , A61B34/10 , A61B34/00 , G16H40/40 , A61B90/00
摘要： A planning tool, system and method include a processor (114) and memory (116) coupled to the processor which stores a planning module (144). A user interface (120) is coupled to the processor and configured to permit a user to select a path through a pathway system (148). The planning module is configured to upload one or more slices of an image volume (111) corresponding to a user-controlled cursor point (108) guided using the user interface such that as the path is navigated the one or more slices are updated in accordance with a depth of the cursor point in the path.
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公开(公告)号：US10219773B2
公开(公告)日：2019-03-05
申请号：US14418471
申请日：2013-07-29
摘要： An imaging system (10) analyzes airways of a patient. The system (10) includes a hardware phantom (50) including tubes (54) representative of airways. The tubes (54) include different lumen sizes and/or wall thicknesses. The system further includes an imaging scanner (12) for scanning a region of interest (ROI), including the airways, and the hardware phantom (50) to create raw image data. At least one processor (32) is programmed to at least one of: (1) correct measurements of walls of the airways based on measurements of lumen size and/or wall thickness of the tubes (54) and known lumen size and/or wall thickness of the tubes (54); and (2) generate an image of the ROI in which color and/or opacity of the airways are based on a comparison of images or maps of the tubes (54) and images or maps of the airways. A corresponding method is also provided.
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10.发明申请公开(公告)号：US20170091934A1
公开(公告)日：2017-03-30
申请号：US15310844
申请日：2015-05-05
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06T7/11 , G06T7/149 , G06T7/174 , G06T2207/10132 , G06T2207/30044
摘要： A model-based segmentation system includes a plurality of clusters (48), each cluster being formed to represent an orientation of a target to be segmented. One or more models (140) are associated with each cluster. The one or more models include an aspect associated with the orientation of the cluster, for example, the appearance of the target to be segmented. A comparison unit (124), configured in memory storage media, is configured to compare an ultra-sound image to the clusters to determine a closest matching orientation and is configured to select the one or more models based upon the cluster with the closest matching orientation. A model adaptation module (126) is configured to adapt the one or more models to the ultrasound image.
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