发明授权
- 专利标题： HPV epitopes targeted by T cells infiltrating cervical malignancies for use in vaccines
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申请号： US14453286申请日： 2014-08-06
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公开(公告)号： US09764023B2公开(公告)日： 2017-09-19
- 发明人: Sjoerd Henricus Van Der Burg , Gemma G. Kenter , Cornelis Johannes Melief
- 申请人： Academisch Ziekenhuis Leiden H.O.D.N. LUMC
- 申请人地址： NL Leiden
- 专利权人： Academish Ziekenhuis Leiden H.O.D.N. LUMC
- 当前专利权人： Academish Ziekenhuis Leiden H.O.D.N. LUMC
- 当前专利权人地址： NL Leiden
- 代理机构： Foley & Lardner LLP
- 代理商 Gilberto M. Villacorta; Sunit Talapatra
- 优先权： EP07109281 20070531; EP07109287 20070531
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; C07K14/005 ; C12N7/00 ; A61K39/00 ; A61K38/00
摘要：
The present invention relates to novel CD4+ and CD8+ T cell epitopes that are specific for HPV-specific E6 and E7 oncoproteins, to peptides comprising these novel T cell epitopes, and to (vaccine) compositions comprising these peptides for use in methods for the prevention and/or treatment of HPV related diseases. Preferred epitopes are recognized by a T cell that infiltrates a cervical neoplastic lesion or by a T cell from a draining lymph node, and are presented by an HLA-DQ or HLA-DP molecule, or an HLA-B.
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