A vacuum assisted dehydration system including a vacuum chamber, a gas compressor, a heating coil, and a vacuum pump is provided. A sealing member removably attached to an opening of the vacuum chamber is opened to introduce one or more instruments into the vacuum chamber. The gas compressor, in fluid communication with the vacuum chamber, recirculates a pressurized gas into the vacuum chamber. The heating coil within the vacuum chamber heats the recirculating gas, which contacts the instruments positioned therein and transfers heat energy into interstitial cavities and to surfaces of the instruments or onto other moist components, for example, hands to vaporize moisture present therein. The vacuum pump, in fluid communication with the vacuum chamber, creates a negative gas pressure in the vacuum chamber to exhaust the vaporized moisture entrained in the heated recirculating gas from the vacuum chamber to dehydrate the instruments or the moist components.