Invention Grant
- Patent Title: Preparation method of 3,7,11-trimethyldodec-2,4,6,10-tetraene-1-yl-phosphonic salt
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Application No.: US14369102Application Date: 2012-12-10
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Publication No.: US09765098B2Publication Date: 2017-09-19
- Inventor: Chunlei Lv , Shiqing Pi , Jianhui Chen , Dingqiang Lu , Pingkai Ouyang
- Applicant: NANJING UNIVERSITY OF TECHNOLOGY , Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
- Applicant Address: CN Nanjing CN Donglu
- Assignee: Nanjing University of Technology,Zhejiang Medicine Co., Ltd.
- Current Assignee: Nanjing University of Technology,Zhejiang Medicine Co., Ltd.
- Current Assignee Address: CN Nanjing CN Donglu
- Agent Christopher Casieri; William Hare
- Priority: CN201110440231 20111226
- International Application: PCT/CN2012/001668 WO 20121210
- International Announcement: WO2013/097286 WO 20130704
- Main IPC: C07F9/54
- IPC: C07F9/54 ; C07F9/00
Abstract:
Provided in the present invention is a preparation method for a phosphonic salt, comprising the step of: reacting 3,7,11-trimethyldodec-1,4,6,10-tetraene-3-ol with triarylphosphine and an acid in an alcohol solvent at 50-100° C. to form the phosphonic salt, wherein the acid is a sulfamic acid or methanesulfonic acid, and the alcohol solvent is a straight chain monohydric alcohol containing 1-5 carbon atoms. The method is performed in nearly neutral conditions, greatly reducing the generation of impurities and greatly obtaining phosphonic salt with an increased E content. The yield of lycopene obtained by using the phosphonic salt as a raw material is high.
Public/Granted literature
- US20140378709A1 PREPARATION METHOD OF 3,7,11- TRIMETHYLDODEC -2,4,6,10-TETRAENE-1-YL-PHOSPHONIC SALT Public/Granted day:2014-12-25
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